HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	37270563, 25402006, 24658140, 12070153, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, ubiquitin reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1210
+	Hs
		363635 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		362614 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		155946 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB4_HUMAN (1-1208): 0: 1155: 49.12
+	Hs
		155890 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		410529 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		155909 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		462985 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		ERBB3_HUMAN (1-1205): 0: 1102: 41.39
+	Hs
		462999 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22
+	Hs
		462998 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79
+	Hs
		155897 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53
+	Hs
		1060799 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		ACK1_HUMAN (691-967): 4.56e-56: 214: 39.58
+	Hs
		463070 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		ACK1_HUMAN (691-967): 4.56e-56: 214: 39.58
+	Mm
		205456 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		FAK1_MOUSE (716-991): 6.02e-54: 207: 37.68
+	Hs
		155933 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		116828 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		463067 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		116830 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Mm
		205454 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		INSR_MOUSE (336-637): 2.12e-27: 122: 21.64
+	Hs
		155150 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64
+	Hs
		155892 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		INSR_HUMAN (336-637): 2.63e-27: 122: 21.64