HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	12470648
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 894
+	Mm
		813512 FYN_MOUSE (35-223): 2.91e-47: 164: 14.80		EPHA4_MOUSE (2-836): 0: 647: 19.32
+	Hs
		462999 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EPHB2_HUMAN (2-821): 0: 618: 19.70
+	Hs
		462998 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		EPHA2_HUMAN (1-843): 0: 616: 19.51
+	Hs
		155150 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		INSR_HUMAN (272-851): 3.88e-136: 441: 27.97
+	Hs
		155892 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		INSR_HUMAN (272-851): 3.88e-136: 441: 27.97
+	Mm
		205454 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		INSR_MOUSE (232-851): 5.8e-135: 438: 26.37
+	Hs
		155898 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		MET_HUMAN (536-799): 3.43e-66: 243: 45.90
+	Hs
		462950 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		MET_HUMAN (536-799): 3.43e-66: 243: 45.90
+	Hs
		471958 HCK_HUMAN (14-223): 1e-48: 168: 16.26		MET_HUMAN (536-799): 3.43e-66: 243: 45.90
+	Hs
		273302 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		MET_HUMAN (536-799): 3.43e-66: 243: 45.90
+	Mm
		591104 FYN_MOUSE (35-223): 2.91e-47: 164: 14.80		MET_MOUSE (536-799): 5.49e-66: 243: 45.90
+	Mm
		205456 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		FAK1_MOUSE (527-889): 3.61e-57: 215: 34.95
+	Hs
		155933 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		FAK1_HUMAN (527-851): 1.73e-56: 213: 36.83
+	Hs
		463067 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FAK1_HUMAN (527-851): 1.73e-56: 213: 36.83
+	Hs
		116828 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		I6L996_HUMAN (527-851): 5.44e-57: 210: 36.83
+	Hs
		116830 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		I6L996_HUMAN (527-851): 5.44e-57: 210: 36.83
+	Hs
		462961 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FGFR1_HUMAN (505-815): 6.73e-56: 209: 40.12
+	Hs
		473401 HCK_HUMAN (14-223): 1e-48: 168: 16.26		FAK1_HUMAN (527-851): 1.73e-56: 213: 36.83
+	Mm
		757443 FYN_MOUSE (35-223): 2.91e-47: 164: 14.80		FAK1_MOUSE (527-889): 3.61e-57: 215: 34.95
+	Hs
		155897 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		IGF1R_HUMAN (234-385): 4.84e-12: 72.4: 18.07