HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 740
+	Hs
		908111 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		KS6A3_HUMAN (1-740): 0: 843: 100.00
+	Hs
		1148402 WHRN_HUMAN (4-306): 1.89e-43: 162: 21.61		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		908117 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KS6A3_HUMAN (1-740): 0: 843: 100.00
+	Hs
		1118434 SNTB1_HUMAN (5-347): 1.02e-40: 152: 16.07		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148392 PDZD7_HUMAN (15-315): 1.31e-29: 122: 20.97		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1122237 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148334 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148344 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148345 MAGI3_HUMAN (17-285): 1.89e-18: 88.9: 16.39		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148381 MAGI1_HUMAN (3-318): 2.73e-18: 88.5: 15.34		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148349 PZRN4_HUMAN (143-342): 6.35e-18: 87.3: 17.62		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1006070 DLG4_HUMAN (88-235): 2.26e-13: 73.1: 19.36		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		1148355 MAGI2_HUMAN (94-316): 6.18e-10: 62.7: 14.54		KS6A1_HUMAN (1-738): 0: 782: 78.11
+	Hs
		162792 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		AKT1_HUMAN (327-739): 8.35e-125: 382: 21.02
+	Hs
		605672 SNTB1_HUMAN (5-347): 1.02e-40: 152: 16.07		KAPCA_HUMAN (403-714): 2.31e-117: 358: 28.31
+	Hs
		728285 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		AKT1_HUMAN (327-739): 8.35e-125: 382: 21.02
+	Hs
		1122234 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		KS6A2_HUMAN (7-332): 8.56e-100: 325: 23.67
+	Mm
		1223775 DLG4_MOUSE (88-235): 2.22e-13: 73.1: 19.36		KS6A2_MOUSE (7-332): 1.02e-103: 335: 24.56
+	Hs
		1091500 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		KS6A2_HUMAN (7-332): 8.56e-100: 325: 23.67
+	Hs
		122954 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		SGK1_HUMAN (428-724): 5.76e-27: 116: 29.36