HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: KCTD2 (Q14681)
BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)
Gene: KCTD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 263
+	Hs
		162869 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		KCTD5_HUMAN (66-263): 2.39e-71: 220: 80.81
+	Hs
		162848 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		SHKB1_HUMAN (57-183): 5.77e-35: 134: 40.95
+	Hs
		162876 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		KCTD3_HUMAN (65-183): 8.56e-34: 131: 42.02
+	Hs
		1130013 DLG3_HUMAN (14-292): 1.13e-29: 122: 14.24		KCTD2_HUMAN (1-263): 3.55e-82: 248: 100.00
+	Hs
		1130005 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KCTD2_HUMAN (1-263): 3.55e-82: 248: 100.00
+	Hs
		1130008 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		KCTD2_HUMAN (1-263): 3.55e-82: 248: 100.00
+	Mm
		1190949 Q3UVD6_MOUSE (2-347): 7.67e-41: 151: 13.66		BACD1_MOUSE (34-252): 3.72e-56: 184: 21.17
+	Hs
		1150493 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KCTD5_HUMAN (66-263): 2.39e-71: 220: 80.81
+	Hs
		1212245 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		KCTD5_HUMAN (66-263): 2.39e-71: 220: 80.81
+	Mm
		999792 DLG3_MOUSE (1-285): 9.86e-30: 122: 14.61		BACD1_MOUSE (34-252): 3.72e-56: 184: 21.17
+	Hs
		1122302 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		KCNB2_HUMAN (37-219): 4.63e-46: 166: 22.22
+	Hs
		1150451 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KCD17_HUMAN (72-254): 2.47e-57: 187: 72.13
+	Hs
		1212227 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		KCD17_HUMAN (72-254): 2.47e-57: 187: 72.13
+	Hs
		1150485 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		BACD3_HUMAN (37-253): 7.82e-55: 180: 25.23
+	Hs
		1122291 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		SHKB1_HUMAN (57-183): 5.77e-35: 134: 40.95
+	Hs
		1150456 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		SHKB1_HUMAN (57-183): 5.77e-35: 134: 40.95
+	Hs
		1212228 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		SHKB1_HUMAN (57-183): 5.77e-35: 134: 40.95
+	Hs
		1150509 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		KCTD3_HUMAN (65-183): 8.56e-34: 131: 42.02
+	Hs
		1212249 NHRF3_HUMAN (1-120): 5.05e-21: 95.9: 34.96		KCTD3_HUMAN (65-183): 8.56e-34: 131: 42.02
+	Hs
		1401147 MAGI1_HUMAN (3-318): 2.73e-18: 88.5: 15.34		KCTD3_HUMAN (65-183): 8.56e-34: 131: 42.02