HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2390 Hs			1 509
+	Hs
		411676 SPTB2_HUMAN (3-2390): 0: 712: 61.09		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		164555 SPTN2_HUMAN (1-2390): 0: 715: 100.00		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433700 SPTB2_HUMAN (3-2390): 0: 712: 61.09		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		211480 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		411637 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411715 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433640 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		521454 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433753 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		337296 SPTA1_HUMAN (182-1386): 5.78e-93: 340: 19.37		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		360640 SPTA1_HUMAN (182-1386): 5.78e-93: 340: 19.37		BTK_HUMAN (7-505): 1.49e-167: 490: 33.27
+	Hs
		337470 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		521527 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		BTK_HUMAN (7-505): 1.49e-167: 490: 33.27
+	Hs
		411682 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		297808 K0754_HUMAN (213-1350): 3.32e-31: 137: 15.09		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433543 DMD_HUMAN (275-2194): 6.97e-24: 113: 8.91		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433710 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		LYN_HUMAN (1-509): 0: 582: 62.72