HitPredict

Interactor 1: CCNE3 (O42575)
G1/S-specific cyclin-E3
Gene: cyce3

Interactor 2: CDK2 (P23437)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (CDC2 homolog Eg1 protein kinase) (Cell division protein kinase 2)
Gene: CDK2

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9922449
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Xl			1 297
+	Hs
		624539 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53
+	Hs
		624573 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDK3_HUMAN (1-294): 5.04e-149: 421: 76.53
+	Rn
		70081 B1WC54_RAT (5-406): 3.58e-125: 369: 57.96		Q6P751_RAT (1-296): 1.36e-153: 432: 88.85
+	Hs
		414745 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52
+	Mm
		956330 CCNE1_MOUSE (1-406): 7.13e-124: 366: 57.39		CDK2_MOUSE (1-296): 7.55e-145: 412: 76.45
+	Hs
		624575 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDK5_HUMAN (1-292): 2.67e-136: 388: 60.07
+	Mm
		509485 CCNE1_MOUSE (1-406): 7.13e-124: 366: 57.39		CDK1_MOUSE (1-289): 2.43e-139: 396: 66.21
+	Hs
		624564 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDK7_HUMAN (2-294): 1.92e-125: 363: 43.92
+	Hs
		303829 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53
+	Hs
		331629 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDK2_HUMAN (1-296): 1.26e-153: 432: 89.53
+	Hs
		331637 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDK3_HUMAN (1-294): 5.04e-149: 421: 76.53
+	Hs
		303821 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52
+	At
		621704 CCB23_ARATH (2-356): 8.15e-102: 310: 21.21		CDKA1_ARATH (1-289): 9.89e-141: 400: 67.93
+	Hs
		331626 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDK1_HUMAN (1-289): 2.44e-140: 399: 65.52
+	Hs
		303843 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDK5_HUMAN (1-292): 2.67e-136: 388: 60.07
+	At
		1321297 CCB23_ARATH (2-356): 8.15e-102: 310: 21.21		CDKD1_ARATH (2-296): 3.4e-133: 385: 48.48
+	At
		1103371 CCB23_ARATH (2-356): 8.15e-102: 310: 21.21		CKB12_ARATH (1-291): 2.41e-133: 381: 55.99
+	At
		639373 CCB24_ARATH (3-357): 1.3e-103: 315: 20.33		CKB11_ARATH (1-291): 1.21e-125: 362: 54.72
+	At
		639365 CCB23_ARATH (2-356): 8.15e-102: 310: 21.21		CKB11_ARATH (1-291): 1.21e-125: 362: 54.72
+	Hs
		303844 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDK17_HUMAN (1-289): 2.96e-108: 325: 54.30