HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2)
Gene: SOCS2

Interactor 2: CISH (Q62225)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	16684815, 16956890
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, transcriptional complementation assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination GO:0035556 - intracellular signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 198 Mm			1 257
+	Rn
		73321 SOCS2_RAT (1-198): 1.75e-65: 201: 97.98		B1WBX9_RAT (1-257): 2.33e-73: 226: 96.11
+	Hs
		155065 SOCS2_HUMAN (1-198): 2.9e-64: 198: 93.94		YES_HUMAN (31-252): 5.88e-50: 173: 13.52
+	Mm
		205440 SOCS2_MOUSE (1-198): 4.38e-65: 200: 100.00		SOCS2_MOUSE (41-257): 1.7e-50: 165: 37.33
+	Rn
		312645 SOCS2_RAT (1-198): 1.75e-65: 201: 97.98		SOCS2_RAT (41-257): 1.56e-49: 163: 37.79
+	Rn
		312646 SOCS2_RAT (1-198): 1.75e-65: 201: 97.98		SOCS3_RAT (51-253): 5.06e-48: 160: 29.67
+	Hs
		155063 SOCS2_HUMAN (1-198): 2.9e-64: 198: 93.94		LCK_HUMAN (2-251): 1.06e-44: 158: 12.17
+	Hs
		155048 SOCS2_HUMAN (1-198): 2.9e-64: 198: 93.94		SOCS3_HUMAN (51-253): 2.31e-46: 156: 30.14
+	Rn
		108117 SOCS2_RAT (1-198): 1.75e-65: 201: 97.98		G3V6B4_RAT (59-257): 5.3e-43: 146: 28.36
+	Hs
		155053 SOCS2_HUMAN (1-198): 2.9e-64: 198: 93.94		SOCS1_HUMAN (59-257): 6.43e-44: 149: 28.36
+	Hs
		155151 SOCS7_HUMAN (31-196): 1.22e-50: 173: 31.03		YES_HUMAN (31-252): 5.88e-50: 173: 13.52
+	Mm
		205416 SOCS2_MOUSE (1-198): 4.38e-65: 200: 100.00		SOCS1_MOUSE (59-257): 9.37e-43: 146: 28.36
+	Hs
		155896 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		YES_HUMAN (31-252): 5.88e-50: 173: 13.52
+	Dm
		1262100 Q8INY1_DROME (36-197): 1.4e-45: 161: 29.27		Q7JVF1_DROME (26-256): 4.54e-47: 161: 25.00
+	Hs
		155893 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		LCK_HUMAN (2-251): 1.06e-44: 158: 12.17
+	Hs
		155925 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		BLK_HUMAN (9-251): 2.39e-44: 158: 14.33
+	Hs
		155157 SOCS7_HUMAN (31-196): 1.22e-50: 173: 31.03		GRB2_HUMAN (34-217): 1.58e-40: 140: 15.84
+	Mm
		571265 FGR_MOUSE (14-174): 1.22e-43: 154: 19.39		FGR_MOUSE (8-252): 5.62e-45: 159: 11.51
+	Hs
		155888 SOCS3_HUMAN (28-194): 1.97e-49: 161: 29.59		ABL1_HUMAN (33-255): 2.41e-40: 149: 11.62