HitPredict

Interactor 1: SI1L1 (O43166)
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Gene: SIPA1L1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	26186194, 28514442, 29395067, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1804 Hs			1 669
+	Hs
		208601 SI1L1_HUMAN (1-1804): 0: 1409: 100.00		LZTS3_HUMAN (1-669): 8.99e-32: 133: 31.33
+	Hs
		1411354 SI1L2_HUMAN (1-1802): 0: 1292: 48.18		LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00
+	Hs
		208680 SI1L1_HUMAN (1-1804): 0: 1409: 100.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		1454568 SI1L2_HUMAN (1-1802): 0: 1292: 48.18		LZTS1_HUMAN (26-653): 1.4e-35: 144: 34.75
+	Hs
		175999 SI1L2_HUMAN (1-1802): 0: 1292: 48.18		N4BP3_HUMAN (17-640): 2.91e-35: 142: 27.16
+	Hs
		244902 SI1L2_HUMAN (1-1802): 0: 1292: 48.18		LZTS3_HUMAN (1-669): 8.99e-32: 133: 31.33
+	Hs
		1226303 SI1L2_HUMAN (1-1802): 0: 1292: 48.18		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		244604 SI1L3_HUMAN (9-1797): 0: 1024: 43.87		LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00
+	Hs
		244515 SI1L3_HUMAN (9-1797): 0: 1024: 43.87		LZTS3_HUMAN (1-669): 8.99e-32: 133: 31.33
+	Hs
		244542 SI1L3_HUMAN (9-1797): 0: 1024: 43.87		MYH9_HUMAN (40-669): 1.08e-16: 86.6: 10.13
+	Hs
		244596 SI1L3_HUMAN (9-1797): 0: 1024: 43.87		MY18A_HUMAN (320-525): 1.14e-09: 64: 19.46
+	Hs
		244583 SI1L3_HUMAN (9-1797): 0: 1024: 43.87		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		1390851 SIPA1_HUMAN (214-1250): 0: 578: 36.81		LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00
+	Hs
		890853 TSC2_HUMAN (103-864): 2.95e-174: 577: 14.02		PHLB1_HUMAN (8-631): 1.93e-26: 117: 14.83
+	Hs
		772955 SIPA1_HUMAN (214-1250): 0: 578: 36.81		MYH9_HUMAN (40-669): 1.08e-16: 86.6: 10.13
+	Hs
		157445 RGPA2_HUMAN (302-839): 4.54e-132: 458: 16.96		CTRO_HUMAN (295-638): 1.1e-11: 70.4: 17.03
+	Hs
		1081697 RGPA2_HUMAN (302-839): 4.54e-132: 458: 16.96		CGNL1_HUMAN (326-667): 1.66e-10: 66.7: 15.80
+	Hs
		1135341 RGPA1_HUMAN (244-840): 3.69e-113: 401: 14.96		SLMAP_HUMAN (327-641): 2.81e-23: 107: 19.59
+	Hs
		1143196 KMT2C_HUMAN (1143-1710): 5.17e-18: 93.7: 8.87		PLEC_HUMAN (327-659): 1.62e-09: 63.5: 20.77
+	Hs
		158047 PCLO_HUMAN (1009-1577): 3.71e-11: 70.8: 11.69		CTRO_HUMAN (295-638): 1.1e-11: 70.4: 17.03