Protein: SI1L1
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

Gene: SI1L1, SIPA1L1
Organism: Homo sapiens
Interactions: 173
UniProt ID: O43166

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0014069 - postsynaptic density
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208651

DLG4
Disks large homolog 4

3

4

Small-scale

0.878

High

208642

AFAD
Afadin

2

18

High-throughput

0.754

High

208691

TRI67
Tripartite motif-containing protein 67

2

7

Small-scale

0.754

High

208727

LZTS2
Leucine zipper putative tumor suppressor 2

5

20

High-throughput

0.712

High

208626

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

208603

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.698

High

208600

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

11

High-throughput

0.691

High

208746

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

9

High-throughput

0.691

High

208647

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

208622

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

208606

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

1

High-throughput

0.667

High

208650

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

208655

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

208729

WDR83
WD repeat domain-containing protein 83

4

5

High-throughput

0.630

High

208602

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.618

High

208612

RASK
GTPase KRas

1

16

High-throughput

0.618

High

208649

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

208659

ZO1
Tight junction protein 1

1

11

High-throughput

0.618

High

208661

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

6

High-throughput

0.618

High

208662

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.618

High

208678

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.618

High

208709

PARD3
Partitioning defective 3 homolog

1

15

High-throughput

0.618

High

208722

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

12

High-throughput

0.618

High

208732

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

9

Small-scale

0.618

High

208748

ZO2
Tight junction protein 2

1

8

High-throughput

0.618

High

208759

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

7

High-throughput

0.618

High

208764

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.618

High

208665

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

12

High-throughput

0.611

High

208627

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

208641

EPHA4
Ephrin type-A receptor 4

1

6

High-throughput

0.590

High

208743

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

208745

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

208609

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

208630

CTNB1
Catenin beta-1

2

4

High-throughput

0.584

High

208643

HDAC4
Histone deacetylase 4

2

2

High-throughput

0.584

High

208613

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

208676

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.553

High

208669

CEBPE
CCAAT/enhancer-binding protein epsilon

1

3

Small-scale

0.552

High

208601

LZTS3
Leucine zipper putative tumor suppressor 3

1

17

High-throughput

0.536

High

208617

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

208634

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

208702

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

208719

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.536

High

208680

CP135
Centrosomal protein of 135 kDa

2

4

High-throughput

0.533

High

208753

FBW1B
F-box/WD repeat-containing protein 11

2

6

Small-scale

0.533

High

208718

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

208633

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.489

High

208640

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.489

High

208714

SPSB4
SPRY domain-containing SOCS box protein 4

1

9

High-throughput

0.489

High

208765

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

12

High-throughput

0.489

High

208644

NRX1B
Neurexin-1-beta

1

1

Small-scale

0.481

High

208656

UBE3A
Ubiquitin-protein ligase E3A

1

4

Small-scale

0.481

High

176784

DCLK1
Serine/threonine-protein kinase DCLK1

1

1

High-throughput

0.479

High

208599

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.479

High

208608

TRI37
E3 ubiquitin-protein ligase TRIM37

1

9

High-throughput

0.479

High

208611

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

208614

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

208618

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

208619

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

208620

NF1
Neurofibromin

1

6

High-throughput

0.479

High

208621

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

208624

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

208625

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

208629

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

208635

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.479

High

208636

GSK3A
Glycogen synthase kinase-3 alpha

1

9

High-throughput

0.479

High

208637

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.479

High

208638

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.479

High

208645

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.479

High

208646

ARP3
Actin-related protein 3

1

7

High-throughput

0.479

High

208648

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.479

High

208653

CDK16
Cyclin-dependent kinase 16

1

3

High-throughput

0.479

High

208654

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

208663

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

208666

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.479

High

208667

ZN638
Zinc finger protein 638

1

2

High-throughput

0.479

High

208668

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

5

High-throughput

0.479

High

208670

ZYX
Zyxin

1

4

High-throughput

0.479

High

208671

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

208672

OCLN
Occludin

1

4

High-throughput

0.479

High

208674

AMOT
Angiomotin

1

7

High-throughput

0.479

High

208677

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.479

High

208679

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

208682

FTM
Protein fantom

1

8

High-throughput

0.479

High

208686

LARP1
La-related protein 1

1

3

High-throughput

0.479

High

208687

SAS6
Spindle assembly abnormal protein 6 homolog

1

5

High-throughput

0.479

High

208690

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

208693

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.479

High

208698

PHLB2
Pleckstrin homology-like domain family B member 2

1

8

High-throughput

0.479

High

208699

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

208700

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

208701

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

208703

NIN
Ninein

1

10

High-throughput

0.479

High

208704

NAV1
Neuron navigator 1

1

5

High-throughput

0.479

High

208710

HDAC7
Histone deacetylase 7

1

2

High-throughput

0.479

High

208711

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.479

High

208724

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

208731

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.479

High

208734

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

208735

PKHA5
Pleckstrin homology domain-containing family A member 5

1

6

High-throughput

0.479

High

208736

TANC2
Protein TANC2

1

2

High-throughput

0.479

High

208737

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.479

High

208738

ANLN
Anillin

1

3

High-throughput

0.479

High

208740

LATS2
Serine/threonine-protein kinase LATS2

1

8

High-throughput

0.479

High

208747

CING
Cingulin

1

3

High-throughput

0.479

High

208749

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

208750

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

208751

NGAP
Ras GTPase-activating protein nGAP

1

6

High-throughput

0.479

High

208758

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

208760

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.479

High

208766

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.479

High

123292

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

208604

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

208605

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

208631

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

208658

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

208673

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.458

High

208694

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

208723

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

208733

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

208741

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

208752

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

208757

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

208657

FMR1
Fragile X messenger ribonucleoprotein 1

1

4

High-throughput

0.457

High

208755

NRX1A
Neurexin-1

1

2

Small-scale

0.457

High

208616

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

208632

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

208688

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

1

Small-scale

0.445

High

174461

TRI66
Tripartite motif-containing protein 66

1

5

High-throughput

0.437

High

208607

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.437

High

208639

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.437

High

208660

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.437

High

208675

ODFP2
Outer dense fiber protein 2

1

5

High-throughput

0.437

High

208681

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

208683

AN34A
Ankyrin repeat domain-containing protein 34A

1

2

High-throughput

0.437

High

208685

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.437

High

208689

GGYF2
GRB10-interacting GYF protein 2

1

11

High-throughput

0.437

High

208692

CE128
Centrosomal protein of 128 kDa

1

9

High-throughput

0.437

High

208697

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.437

High

208705

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

208706

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

208707

DEN1A
DENN domain-containing protein 1A

1

4

High-throughput

0.437

High

208708

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

4

High-throughput

0.437

High

208712

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.437

High

208713

ESR2
Estrogen receptor beta

1

17

High-throughput

0.437

High

208715

SPDLY
Protein Spindly

1

4

High-throughput

0.437

High

208720

CEP63
Centrosomal protein of 63 kDa

1

8

High-throughput

0.437

High

208725

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

208744

SEP10
Septin-10

1

1

High-throughput

0.437

High

208762

NINL
Ninein-like protein

1

11

High-throughput

0.437

High

208763

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

208761

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.426

High

94297

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

191265

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

2

High-throughput

0.407

High

208664

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

208695

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

208717

STALP
AMSH-like protease

3

0

High-throughput

0.345

High

208615

PIP
Prolactin-inducible protein

2

0

High-throughput

0.313

High

208684

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

208696

CENPU
Centromere protein U

1

0

High-throughput

0.279

Low

208610

NADK
NAD kinase

1

0

High-throughput

0.249

Low

208623

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.249

Low

208716

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

208721

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

208726

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

208728

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

208730

RTKN
Rhotekin

1

0

High-throughput

0.249

Low

208742

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

208756

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.249

Low

208628

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.232

Low

208652

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.232

Low

208739

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.232

Low

208754

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025