HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25766326, 18414007, 33069770
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 595
+	Hs
		214106 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64
+	Hs
		659722 SPOPL_HUMAN (1-374): 1.16e-118: 350: 80.36		RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64
+	Hs
		1120792 KLH12_HUMAN (180-373): 2.62e-64: 216: 22.68		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1049287 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		377784 KLHL3_HUMAN (152-371): 2.59e-59: 203: 22.73		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		214030 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14
+	Dm
		1259329 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q8WS79_DROME (183-488): 2.28e-50: 183: 35.37
+	Dm
		1365583 RDX_DROME (1-374): 5.65e-111: 344: 79.41		Q9VSE9_DROME (183-488): 1.58e-50: 183: 35.37
+	Hs
		611438 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		214052 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		659742 KLH11_HUMAN (199-328): 4.53e-13: 72.4: 31.21		RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64