HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1250
+	Hs
		594029 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		RAPH1_HUMAN (1-1250): 0: 638: 100.00
+	Mm
		686967 P85A_MOUSE (166-379): 9.21e-25: 107: 16.36		GRB10_MOUSE (70-592): 4.87e-147: 459: 22.03
+	Hs
		473417 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		GRB14_HUMAN (160-623): 5.63e-138: 433: 24.26
+	Hs
		699733 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		440538 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		902832 BLK_HUMAN (7-204): 7.94e-20: 92.9: 19.80		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		557281 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		987609 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		319045 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		K0754_HUMAN (507-1078): 3.16e-29: 129: 15.21
+	Hs
		699722 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		274251 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ANR17_HUMAN (649-1240): 1.53e-13: 77.9: 12.50
+	Hs
		440048 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		557261 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		987587 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		463316 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		439935 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		557066 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		440773 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		MAGL2_HUMAN (498-1221): 3.59e-13: 76.7: 11.68
+	Hs
		590268 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		66953 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		L37A2_HUMAN (512-1024): 1.51e-10: 68.1: 16.01