HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1250
+	Hs
		222124 NCK2_HUMAN (1-376): 1.95e-92: 283: 68.24		RAPH1_HUMAN (1-1250): 0: 638: 100.00
+	Mm
		686967 P85A_MOUSE (241-376): 7.29e-23: 102: 19.57		GRB10_MOUSE (70-592): 4.87e-147: 459: 22.03
+	Hs
		473417 HCK_HUMAN (2-190): 3.43e-21: 96.8: 16.84		GRB14_HUMAN (160-623): 5.63e-138: 433: 24.26
+	Hs
		440538 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		699733 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		987609 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Hs
		557281 SRC_HUMAN (5-152): 5.68e-12: 68.8: 19.74		GRB10_HUMAN (111-595): 4.33e-117: 379: 25.15
+	Ce
		711444 SEM5_CAEEL (3-67): 2.72e-16: 79.4: 32.31		MIG10_CAEEL (190-656): 1.8e-87: 303: 32.14
+	Dm
		1061469 GRAP_DROME (1-61): 1.17e-17: 82.7: 31.15		Q9VWB7_DROME (252-906): 2.96e-70: 259: 24.85
+	Hs
		699722 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		987587 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		440773 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		MAGL2_HUMAN (498-1221): 3.59e-13: 76.7: 11.68
+	Hs
		557261 SRC_HUMAN (5-152): 5.68e-12: 68.8: 19.74		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		1065074 ITK_HUMAN (3-138): 3.38e-11: 66.7: 21.01		EP300_HUMAN (534-1200): 4.99e-24: 112: 11.59
+	Hs
		590268 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		557066 SRC_HUMAN (5-152): 5.68e-12: 68.8: 19.74		MUC1_HUMAN (785-1245): 3.98e-17: 89.5: 11.50
+	Hs
		274251 ITSN2_HUMAN (7-85): 2.53e-12: 70.6: 24.05		ANR17_HUMAN (649-1240): 1.53e-13: 77.9: 12.50
+	Hs
		987833 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		PRG4_HUMAN (518-1132): 5.15e-10: 66.3: 13.07
+	Dm
		1061466 GRAP_DROME (1-61): 1.17e-17: 82.7: 31.15		Q9VUH6_DROME (769-1249): 3.51e-09: 63.6: 10.35
+	Hs
		66953 SRC_HUMAN (5-152): 5.68e-12: 68.8: 19.74		L37A2_HUMAN (512-1024): 1.51e-10: 68.1: 16.01