HitPredict

Interactor 1: GBG7 (O60262)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene: GNG7

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	28087732, 8636150, 19168127, 16301321, 33961781, 35271311, 40437099, 12782285
Identification Methods	protein complementation assay, two hybrid, affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0045202 - synapse GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 68 Hs			1 340
+	Hs
		243467 GBG7_HUMAN (1-68): 1.23e-28: 98.6: 100.00		GBB2_HUMAN (1-340): 5.18e-107: 318: 90.29
+	Hs
		243474 GBG7_HUMAN (1-68): 1.23e-28: 98.6: 100.00		GBB4_HUMAN (1-340): 2.62e-106: 316: 90.88
+	Hs
		243464 GBG7_HUMAN (1-68): 1.23e-28: 98.6: 100.00		GBB3_HUMAN (1-340): 1.16e-105: 314: 83.24
+	Hs
		984316 GBG12_HUMAN (2-68): 2e-26: 93.2: 77.61		GBB2_HUMAN (1-340): 5.18e-107: 318: 90.29
+	Hs
		948052 GBG2_HUMAN (2-68): 5.05e-26: 92: 70.59		GBB2_HUMAN (1-340): 5.18e-107: 318: 90.29
+	Hs
		1437752 GBG12_HUMAN (2-68): 2e-26: 93.2: 77.61		GBB4_HUMAN (1-340): 2.62e-106: 316: 90.88
+	Hs
		983605 GBG12_HUMAN (2-68): 2e-26: 93.2: 77.61		GBB1_HUMAN (1-340): 1.7e-106: 316: 100.00
+	Hs
		984064 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB2_HUMAN (1-340): 5.18e-107: 318: 90.29
+	Hs
		948051 GBG2_HUMAN (2-68): 5.05e-26: 92: 70.59		GBB1_HUMAN (1-340): 1.7e-106: 316: 100.00
+	Hs
		948081 GBG2_HUMAN (2-68): 5.05e-26: 92: 70.59		GBB4_HUMAN (1-340): 2.62e-106: 316: 90.88
+	Bt
		983440 GBG2_BOVIN (2-68): 5.05e-26: 92: 70.59		GBB1_BOVIN (1-340): 1.7e-106: 316: 100.00
+	Mm
		983624 GBG2_MOUSE (2-68): 5.05e-26: 92: 70.59		GBB1_MOUSE (1-340): 1.7e-106: 316: 100.00
+	Hs
		597375 GBG12_HUMAN (2-68): 2e-26: 93.2: 77.61		GBB3_HUMAN (1-340): 1.16e-105: 314: 83.24
+	Hs
		983447 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB1_HUMAN (1-340): 1.7e-106: 316: 100.00
+	Hs
		992433 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB4_HUMAN (1-340): 2.62e-106: 316: 90.88
+	Hs
		597349 GBG2_HUMAN (2-68): 5.05e-26: 92: 70.59		GBB3_HUMAN (1-340): 1.16e-105: 314: 83.24
+	Hs
		597353 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GBB3_HUMAN (1-340): 1.16e-105: 314: 83.24
+	Hs
		163603 GBG7_HUMAN (1-68): 1.23e-28: 98.6: 100.00		GNB5_HUMAN (129-340): 6.95e-45: 159: 21.46
+	Hs
		163627 GBG2_HUMAN (2-68): 5.05e-26: 92: 70.59		GNB5_HUMAN (129-340): 6.95e-45: 159: 21.46
+	Hs
		163629 GBG3_HUMAN (1-68): 1.12e-25: 91.2: 60.87		GNB5_HUMAN (129-340): 6.95e-45: 159: 21.46