HitPredict

Interactor 1: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.763

The method score is based on:

Property Details
Experiments 33961781, 10339615, 19168127, 9789084, 15889144, 19376773, 16301321, 35271311, 37450587, 40437099, 15782186, 12782285, 12606627, 18611381, 23739333
Identification Methods affinity chromatography technology, pull down, cross-linking study, fluorescent resonance energy transfer, molecular sieving, ion exchange chromatography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007191 - adenylate cyclase-activating dopamine receptor signaling pathway
GO:0016020 - membrane
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 11Aug2025