HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: FRMD1 (Q8N878)
FERM domain-containing protein 1
Gene: FRMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 549
+	Hs
		248666 PEPL_HUMAN (1-1756): 1.28e-126: 440: 100.00		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		708853 PLEC_HUMAN (8-1204): 4.61e-33: 143: 9.80		PTN4_HUMAN (28-546): 2.7e-111: 354: 15.88
+	Hs
		1330857 EVPL_HUMAN (5-816): 5.46e-14: 80.3: 9.55		FRMD1_HUMAN (1-549): 1.22e-138: 414: 100.00
+	Hs
		582796 GOGB1_HUMAN (1-1063): 3.29e-30: 133: 7.40		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		538892 MYH10_HUMAN (885-1752): 2.64e-37: 156: 12.42		EPB41_HUMAN (10-498): 2.2e-92: 303: 13.26
+	Hs
		683888 CP250_HUMAN (460-1756): 3.6e-40: 166: 11.58		MOES_HUMAN (50-531): 1.29e-91: 293: 15.67
+	Hs
		683840 GOGB1_HUMAN (1-1063): 3.29e-30: 133: 7.40		MOES_HUMAN (50-531): 1.29e-91: 293: 15.67
+	Hs
		538891 MYH9_HUMAN (1146-1756): 1.58e-25: 118: 14.45		EPB41_HUMAN (10-498): 2.2e-92: 303: 13.26
+	Hs
		1134774 NUMA1_HUMAN (2-771): 3.61e-17: 90.7: 11.04		E41L3_HUMAN (7-543): 1.88e-99: 326: 12.77
+	Hs
		217442 NUMA1_HUMAN (2-771): 3.61e-17: 90.7: 11.04		E41L2_HUMAN (6-512): 1.42e-99: 325: 13.74
+	Hs
		1134723 NUMA1_HUMAN (2-771): 3.61e-17: 90.7: 11.04		E41L1_HUMAN (3-458): 4.43e-99: 321: 16.57
+	Hs
		683785 MYH9_HUMAN (1146-1756): 1.58e-25: 118: 14.45		MOES_HUMAN (50-531): 1.29e-91: 293: 15.67
+	Hs
		583026 MACF1_HUMAN (19-1673): 1.12e-10: 69.5: 10.42		EZRI_HUMAN (50-547): 1.13e-104: 328: 16.00
+	Hs
		683829 CENPE_HUMAN (1-955): 1.23e-20: 102: 7.53		MOES_HUMAN (50-531): 1.29e-91: 293: 15.67
+	Hs
		538960 NUMA1_HUMAN (2-771): 3.61e-17: 90.7: 11.04		EPB41_HUMAN (10-498): 2.2e-92: 303: 13.26
+	Hs
		538862 MYH1_HUMAN (8-606): 8.88e-15: 82.6: 8.13		EPB41_HUMAN (10-498): 2.2e-92: 303: 13.26
+	Hs
		538857 SPTB1_HUMAN (130-1478): 5.97e-13: 76.8: 11.71		EPB41_HUMAN (10-498): 2.2e-92: 303: 13.26
+	Hs
		320560 GRDN_HUMAN (1065-1598): 6.35e-11: 70.1: 23.13		FARP2_HUMAN (15-535): 3.42e-91: 303: 13.48
+	Hs
		767516 MACF1_HUMAN (19-1673): 1.12e-10: 69.5: 10.42		RADI_HUMAN (50-501): 4.77e-94: 300: 16.70
+	Hs
		1191489 GRDN_HUMAN (1065-1598): 6.35e-11: 70.1: 23.13		E41LA_HUMAN (51-549): 7.63e-91: 294: 14.21