HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 303
+	Hs
		249727 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		CRK_HUMAN (3-302): 1.42e-51: 173: 54.89
+	Hs
		249716 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		855926 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00
+	Hs
		221984 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		NCK2_HUMAN (13-98): 9.64e-18: 84.4: 29.89
+	Hs
		249715 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81
+	Hs
		855740 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		CRK_HUMAN (3-302): 1.42e-51: 173: 54.89
+	Hs
		249725 DOK2_HUMAN (1-412): 4.66e-151: 435: 100.00		CSK_HUMAN (129-180): 8.47e-11: 64.1: 43.40
+	Mm
		267122 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		NCK1_MOUSE (85-196): 2.33e-16: 80.6: 22.81
+	Mm
		237067 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		NCK2_MOUSE (85-209): 1.31e-14: 75.2: 25.78
+	Mm
		267116 DOK2_MOUSE (1-412): 4.26e-137: 400: 74.04		CSK_MOUSE (129-180): 8.47e-11: 64.1: 43.40
+	Hs
		619097 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Mm
		1021481 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89
+	Hs
		987891 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Mm
		1021485 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		NCK1_MOUSE (85-196): 2.33e-16: 80.6: 22.81
+	Hs
		222185 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		NCK2_HUMAN (13-98): 9.64e-18: 84.4: 29.89
+	Mm
		237073 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		NCK2_MOUSE (85-209): 1.31e-14: 75.2: 25.78
+	Hs
		594088 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81
+	Hs
		584579 DOK1_HUMAN (3-394): 3.41e-108: 328: 35.53		VAV_HUMAN (214-293): 4.71e-14: 74.4: 30.86
+	Mm
		1221263 DOK3_MOUSE (3-395): 1.39e-99: 305: 33.50		GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89
+	Mm
		834249 DOK1_MOUSE (3-393): 1.34e-111: 337: 37.12		CSK_MOUSE (129-180): 8.47e-11: 64.1: 43.40