HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	22974441
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 481
+	Hs
		855926 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		584579 VAV_HUMAN (11-189): 6.63e-47: 170: 28.21		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		619097 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		1021481 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		855664 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		DOK3_HUMAN (1-458): 6.25e-116: 351: 31.21
+	Hs
		249727 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		249728 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		160439 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		160440 CRKL_HUMAN (2-302): 4.59e-59: 193: 47.42		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Mm
		772560 CRK_MOUSE (1-304): 9.45e-70: 220: 99.67		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		249716 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		160410 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		855700 CRK_HUMAN (1-304): 1.27e-69: 220: 100.00		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Hs
		599274 PLCG2_HUMAN (1-301): 3.43e-28: 116: 15.82		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Rn
		772588 GRB2_RAT (135-297): 1.31e-26: 106: 17.05		IRS1_RAT (6-373): 3.7e-78: 267: 17.27
+	Mm
		772556 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		619141 PLCG1_HUMAN (1-302): 3.63e-30: 122: 15.48		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Mm
		1010411 GRB2_MOUSE (135-297): 8.29e-27: 106: 17.51		IRS2_MOUSE (6-371): 1.56e-70: 245: 15.10
+	Rn
		98918 GRB2_RAT (135-297): 1.31e-26: 106: 17.05		F1MAL5_RAT (6-371): 8.48e-69: 240: 15.10
+	Rn
		93208 GRB2_RAT (135-297): 1.31e-26: 106: 17.05		D4A244_RAT (154-464): 1.16e-58: 203: 22.68