HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	25814554, 11071635, 9822717, 11553620, unassigned1126
Identification Methods	two hybrid, pull down, affinity chromatography technology, far western blotting, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 481
+	Hs
		855740 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		619097 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		1021481 GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		249728 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		160440 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		855664 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		DOK3_HUMAN (1-458): 6.25e-116: 351: 31.21
+	Hs
		249727 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Hs
		160439 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		249716 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		DOK2_HUMAN (2-426): 3.35e-116: 349: 34.09
+	Mm
		1221263 GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89		DOK3_MOUSE (1-458): 4.83e-120: 360: 30.90
+	Mm
		772560 CRK_MOUSE (3-302): 9.88e-52: 174: 54.89		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		160410 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		IRS4_HUMAN (6-404): 5.58e-95: 314: 14.35
+	Hs
		599274 PLCG2_HUMAN (5-192): 1.58e-26: 111: 18.23		IRS1_HUMAN (6-373): 1.96e-76: 262: 16.33
+	Hs
		855700 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		FRS2_HUMAN (154-464): 2.54e-54: 191: 21.09
+	Mm
		772556 GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		619141 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Mm
		1010411 GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89		IRS2_MOUSE (6-371): 1.56e-70: 245: 15.10
+	Rn
		98918 GRB2_RAT (126-295): 3.56e-23: 96.8: 15.89		F1MAL5_RAT (6-371): 8.48e-69: 240: 15.10
+	Rn
		93208 GRB2_RAT (126-295): 3.56e-23: 96.8: 15.89		D4A244_RAT (154-464): 1.16e-58: 203: 22.68
+	Mm
		1221241 GRB2_MOUSE (126-295): 2.84e-23: 97.2: 15.89		FRS2_MOUSE (154-464): 4.47e-56: 196: 21.73