HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	20697350
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 377
+	Mm
		237067 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		NCK2_MOUSE (1-376): 1.08e-94: 289: 67.19
+	Hs
		249715 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		NCK1_HUMAN (1-377): 9.82e-102: 307: 98.94
+	Hs
		221984 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		NCK2_HUMAN (1-376): 8.35e-95: 289: 68.50
+	Mm
		1021485 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		NCK1_MOUSE (1-377): 3.99e-102: 308: 100.00
+	Hs
		594088 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		NCK1_HUMAN (1-377): 9.82e-102: 307: 98.94
+	Mm
		237073 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		NCK2_MOUSE (1-376): 1.08e-94: 289: 67.19
+	Hs
		222185 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		NCK2_HUMAN (1-376): 8.35e-95: 289: 68.50
+	Mm
		267114 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		SRC_MOUSE (5-130): 2.56e-17: 85.5: 21.09
+	Mm
		267116 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		CSK_MOUSE (4-138): 2.43e-14: 75.9: 14.89
+	Hs
		249710 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		FYN_HUMAN (5-130): 6.38e-22: 99.1: 21.09
+	Hs
		249714 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		SRC_HUMAN (5-130): 2.54e-17: 85.5: 21.09
+	Hs
		249725 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		CSK_HUMAN (4-138): 3.16e-14: 75.6: 14.89
+	Hs
		249711 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		YES_HUMAN (47-233): 2.33e-10: 63.8: 17.26
+	Mm
		686951 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		P85A_MOUSE (241-376): 7.01e-21: 96.4: 19.57
+	Hs
		699839 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		P85A_HUMAN (241-376): 5.72e-21: 96.7: 19.57
+	Hs
		486706 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		FGR_HUMAN (5-130): 5.02e-21: 96.4: 21.09
+	Mm
		1021481 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		GRB2_MOUSE (3-62): 3.62e-17: 81.3: 28.33
+	Hs
		557444 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		SRC_HUMAN (5-130): 2.54e-17: 85.5: 21.09
+	Mm
		834249 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		CSK_MOUSE (4-138): 2.43e-14: 75.9: 14.89
+	Hs
		463208 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		YES_HUMAN (47-233): 2.33e-10: 63.8: 17.26