HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 784 Hs			1 505
+	Hs
		252311 TLR2_HUMAN (1-784): 5.23e-128: 402: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		191207 TLR3_HUMAN (1-784): 1.44e-77: 270: 18.18		BLK_HUMAN (1-505): 0: 600: 100.00
+	Hs
		126288 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		SRC_HUMAN (1-503): 0: 559: 54.22
+	Mm
		431371 TLR4_MOUSE (1-782): 7.72e-82: 280: 20.91		SRC_MOUSE (1-503): 0: 556: 54.14
+	Hs
		191201 TLR3_HUMAN (1-784): 1.44e-77: 270: 18.18		SRC_HUMAN (1-503): 0: 559: 54.22
+	Hs
		1054160 TLR6_HUMAN (36-781): 7.79e-97: 320: 27.97		BTK_HUMAN (4-498): 2.25e-156: 461: 34.31
+	Hs
		126308 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		BTK_HUMAN (4-498): 2.25e-156: 461: 34.31
+	Mm
		431369 TLR9_MOUSE (6-534): 6.74e-31: 132: 15.74		SRC_MOUSE (1-503): 0: 556: 54.14
+	Hs
		557489 TLR9_HUMAN (3-375): 9.56e-26: 116: 13.66		SRC_HUMAN (1-503): 0: 559: 54.22
+	Mm
		431367 TLR3_MOUSE (264-554): 5.83e-12: 71.4: 13.55		SRC_MOUSE (1-503): 0: 556: 54.14
+	Hs
		1054151 TLR8_HUMAN (38-696): 2.92e-32: 136: 15.46		BTK_HUMAN (4-498): 2.25e-156: 461: 34.31
+	Hs
		1054150 TLR9_HUMAN (3-375): 9.56e-26: 116: 13.66		BTK_HUMAN (4-498): 2.25e-156: 461: 34.31