HitPredict

Interactor 1: SRGP2 (O75044)
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)
Gene: SRGAP2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030027 - lamellipodium
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1071 Hs			1 375
+	Hs
		1122443 RHG12_HUMAN (386-679): 1.14e-65: 240: 22.03		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		64678 RHG32_HUMAN (378-1068): 4.17e-83: 299: 17.14		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		64690 RHG32_HUMAN (378-1068): 4.17e-83: 299: 17.14		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		891832 RHG17_HUMAN (244-1052): 2.89e-79: 280: 13.68		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891744 MYO9B_HUMAN (101-929): 1.2e-75: 276: 13.52		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		112131 M0R0P8_HUMAN (101-929): 8.47e-76: 277: 13.52		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		929850 MYO9B_HUMAN (101-929): 1.2e-75: 276: 13.52		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		891826 RHG21_HUMAN (200-1027): 2.03e-71: 263: 13.52		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891856 RHG27_HUMAN (350-680): 2.61e-72: 260: 20.12		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891894 RHG24_HUMAN (357-975): 1.55e-72: 258: 16.81		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929907 RHG27_HUMAN (350-680): 2.61e-72: 260: 20.12		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		929924 RHG24_HUMAN (357-975): 1.55e-72: 258: 16.81		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		891880 RHG12_HUMAN (386-679): 1.14e-65: 240: 22.03		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929916 RHG12_HUMAN (386-679): 1.14e-65: 240: 22.03		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		787164 RHG25_HUMAN (504-717): 4.18e-15: 82: 27.52		POTEE_HUMAN (1-375): 0: 736: 92.00
+	Hs
		892060 RHG35_HUMAN (502-649): 2.56e-17: 90.1: 31.76		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932401 RHG35_HUMAN (502-649): 2.56e-17: 90.1: 31.76		ACTC_HUMAN (2-375): 0: 592: 94.12