HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	9516124
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019221 - cytokine-mediated signaling pathway GO:0038043 - interleukin-5-mediated signaling pathway GO:0070665 - positive regulation of leukocyte proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 420
+	Hs
		253289 JAK2_HUMAN (1-1132): 0: 1116: 100.00		PRLR_HUMAN (137-396): 9.38e-58: 201: 19.27
+	Mm
		1064402 JAK2_MOUSE (1-1129): 0: 1103: 93.89		PRLR_MOUSE (137-396): 6.76e-57: 198: 18.18
+	Mm
		689975 JAK2_MOUSE (1-1129): 0: 1103: 93.89		IL3RA_MOUSE (4-404): 1.42e-56: 193: 15.96
+	Hs
		253308 JAK2_HUMAN (1-1132): 0: 1116: 100.00		IL2RG_HUMAN (80-400): 8.95e-48: 168: 17.26
+	Hs
		253379 JAK2_HUMAN (1-1132): 0: 1116: 100.00		I12R2_HUMAN (67-342): 2.74e-43: 163: 14.89
+	Hs
		253279 JAK2_HUMAN (1-1132): 0: 1116: 100.00		GHR_HUMAN (106-398): 9.51e-43: 160: 17.54
+	Mm
		599257 JAK2_MOUSE (1-1129): 0: 1103: 93.89		GHR_MOUSE (106-398): 4.79e-42: 158: 15.46
+	Mm
		575632 JAK2_MOUSE (1-1129): 0: 1103: 93.89		EPOR_MOUSE (97-392): 7.51e-41: 153: 17.26
+	Hs
		253294 JAK2_HUMAN (1-1132): 0: 1116: 100.00		EPOR_HUMAN (113-391): 7.75e-35: 136: 18.54
+	Mm
		1025675 JAK2_MOUSE (1-1129): 0: 1103: 93.89		IL6RB_MOUSE (44-378): 1.68e-20: 96.1: 14.33
+	Hs
		253309 JAK2_HUMAN (1-1132): 0: 1116: 100.00		IL3RB_HUMAN (139-344): 4.3e-15: 79.5: 11.95
+	Hs
		253323 JAK2_HUMAN (1-1132): 0: 1116: 100.00		LEPR_HUMAN (38-387): 4.82e-12: 70.2: 15.12
+	Mm
		689977 JAK2_MOUSE (1-1129): 0: 1103: 93.89		IL3B2_MOUSE (139-344): 3.71e-16: 82.6: 15.49
+	Mm
		689979 JAK2_MOUSE (1-1129): 0: 1103: 93.89		IL3RB_MOUSE (139-344): 5.66e-15: 79.1: 16.44
+	Hs
		253315 JAK2_HUMAN (1-1132): 0: 1116: 100.00		IL6RB_HUMAN (12-340): 1.38e-10: 65.3: 9.86
+	Mm
		1021266 JAK2_MOUSE (1-1129): 0: 1103: 93.89		I12R2_MOUSE (40-416): 1.58e-13: 74.5: 14.11
+	Mm
		871460 JAK2_MOUSE (1-1129): 0: 1103: 93.89		LEPR_MOUSE (195-382): 1.68e-10: 65.2: 17.95
+	Hs
		714607 TYK2_HUMAN (38-1132): 0: 861: 35.49		I13R1_HUMAN (27-366): 1.46e-52: 183: 19.83
+	Hs
		533834 TYK2_HUMAN (38-1132): 0: 861: 35.49		GHR_HUMAN (106-398): 9.51e-43: 160: 17.54
+	Hs
		714581 TYK2_HUMAN (38-1132): 0: 861: 35.49		IL6RB_HUMAN (12-340): 1.38e-10: 65.3: 9.86