HitPredict

Interactor 1: IL6RB (Q00560)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: Il6st

Interactor 2: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	23454976
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3
Common GO terms	GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0019221 - cytokine-mediated signaling pathway GO:0042102 - positive regulation of T cell proliferation GO:0043524 - negative regulation of neuron apoptotic process and 1 others more... GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 917 Mm			1 1132
+	Hs
		253315 IL6RB_HUMAN (1-917): 0: 584: 76.82		JAK2_HUMAN (1-1132): 0: 1126: 93.73
+	Mm
		1021266 I12R2_MOUSE (9-886): 1.02e-107: 355: 20.76		JAK2_MOUSE (1-1132): 0: 1153: 100.00
+	Hs
		714581 IL6RB_HUMAN (1-917): 0: 584: 76.82		TYK2_HUMAN (38-1132): 0: 897: 35.73
+	Hs
		253379 I12R2_HUMAN (30-867): 2.77e-93: 315: 20.35		JAK2_HUMAN (1-1132): 0: 1126: 93.73
+	Hs
		473376 IL6RB_HUMAN (1-917): 0: 584: 76.82		HCK_HUMAN (795-1132): 1.91e-93: 310: 29.33
+	Hs
		658647 IL6RB_HUMAN (1-917): 0: 584: 76.82		JAK1_HUMAN (830-1131): 1.31e-35: 149: 19.63
+	Mm
		440273 CSF3R_MOUSE (5-839): 6.09e-103: 341: 21.49		LCK_MOUSE (821-1132): 4e-97: 320: 30.03
+	Mm
		465769 CSF3R_MOUSE (5-839): 6.09e-103: 341: 21.49		HCK_MOUSE (821-1132): 6.76e-91: 303: 30.16
+	Hs
		473464 CSF3R_HUMAN (5-794): 4.04e-100: 333: 24.82		HCK_HUMAN (795-1132): 1.91e-93: 310: 29.33
+	Hs
		463721 CSF3R_HUMAN (5-794): 4.04e-100: 333: 24.82		LYN_HUMAN (804-1132): 1.66e-91: 304: 30.61
+	Hs
		440371 PTPRD_HUMAN (1-846): 6.51e-76: 274: 13.00		FYN_HUMAN (800-1125): 1.18e-96: 319: 27.22
+	Mm
		59107 PTPRF_MOUSE (109-917): 4.96e-68: 250: 11.32		FYN_MOUSE (800-1125): 1.14e-96: 319: 27.22
+	Hs
		440313 PTPRF_HUMAN (127-917): 3.3e-67: 248: 11.40		FYN_HUMAN (800-1125): 1.18e-96: 319: 27.22
+	Hs
		439918 PTPRF_HUMAN (127-917): 3.3e-67: 248: 11.40		LCK_HUMAN (821-1132): 1.51e-96: 318: 29.71
+	Hs
		658762 OSMR_HUMAN (30-819): 2.27e-104: 348: 19.44		JAK1_HUMAN (830-1131): 1.31e-35: 149: 19.63
+	Hs
		658761 CSF3R_HUMAN (5-794): 4.04e-100: 333: 24.82		JAK1_HUMAN (830-1131): 1.31e-35: 149: 19.63
+	Hs
		411450 L1CAM_HUMAN (34-625): 1.66e-75: 271: 14.19		NTRK1_HUMAN (510-808): 5.77e-21: 101: 26.51
+	Hs
		411245 PTPRF_HUMAN (127-917): 3.3e-67: 248: 11.40		NTRK1_HUMAN (510-808): 5.77e-21: 101: 26.51
+	Hs
		541362 L1CAM_HUMAN (34-625): 1.66e-75: 271: 14.19		FGFR1_HUMAN (545-838): 5.83e-13: 75.5: 22.43
+	Hs
		541555 I27RA_HUMAN (139-707): 3.06e-53: 198: 19.72		FGFR1_HUMAN (545-838): 5.83e-13: 75.5: 22.43