HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: DKK4 (Q9UBT3)
Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]
Gene: DKK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 224
+	Hs
		258282 LRP5_HUMAN (27-1615): 0: 1840: 100.00		DKK1_HUMAN (41-220): 4.47e-66: 206: 41.94
+	Hs
		258359 LRP5_HUMAN (27-1615): 0: 1840: 100.00		DKK2_HUMAN (37-221): 5.77e-66: 206: 42.63
+	Hs
		270245 LRP6_HUMAN (8-646): 0: 590: 37.98		DKK1_HUMAN (41-220): 4.47e-66: 206: 41.94
+	Hs
		270344 LRP6_HUMAN (8-646): 0: 590: 37.98		DKK2_HUMAN (37-221): 5.77e-66: 206: 42.63
+	Mm
		222597 LRP6_MOUSE (8-646): 0: 590: 37.54		DKK1_MOUSE (41-220): 1.24e-65: 205: 40.31
+	Hs
		957657 LRP2_HUMAN (1165-1411): 1.07e-11: 72.4: 11.33		DKK2_HUMAN (37-221): 5.77e-66: 206: 42.63
+	Hs
		1269032 SORL_HUMAN (1357-1615): 2.37e-10: 68.2: 9.36		DKK2_HUMAN (37-221): 5.77e-66: 206: 42.63
+	Hs
		1349412 LRP1B_HUMAN (1254-1402): 6.09e-09: 63.5: 24.54		DKK2_HUMAN (37-221): 5.77e-66: 206: 42.63