HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: CD22 (P20273)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	19150402
Identification Methods	pull down, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0050776 - regulation of immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 847
+	Hs
		463325 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		CD22_HUMAN (19-847): 0: 577: 100.00
+	Hs
		629550 SHIP1_HUMAN (4-103): 1.67e-37: 136: 43.00		CD22_HUMAN (19-847): 0: 577: 100.00
+	Hs
		629547 GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69		CD22_HUMAN (19-847): 0: 577: 100.00
+	Mm
		770704 SHIP1_MOUSE (4-103): 9.68e-37: 133: 42.00		CD22_MOUSE (1-847): 5.29e-174: 526: 59.24
+	Mm
		770697 GRB2_MOUSE (1-123): 1.99e-35: 122: 19.69		CD22_MOUSE (1-847): 5.29e-174: 526: 59.24
+	Mm
		770693 KSYK_MOUSE (5-120): 2.8e-15: 72.8: 24.79		CD22_MOUSE (1-847): 5.29e-174: 526: 59.24
+	Hs
		463499 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		PTK7_HUMAN (246-837): 4.87e-64: 235: 14.77
+	Hs
		463707 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		KIRR1_HUMAN (3-500): 6.71e-54: 202: 20.38
+	Hs
		987864 GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69		KIRR1_HUMAN (3-500): 6.71e-54: 202: 20.38
+	Hs
		249921 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		NPHN_HUMAN (12-522): 1.3e-38: 157: 19.25
+	Hs
		249920 FYN_HUMAN (1-125): 4.26e-37: 133: 19.26		NPHN_HUMAN (12-522): 1.3e-38: 157: 19.25
+	Hs
		440359 FYN_HUMAN (1-125): 4.26e-37: 133: 19.26		MAG_HUMAN (153-578): 1.56e-32: 136: 19.67
+	Hs
		462981 YES_HUMAN (1-127): 5.29e-40: 141: 19.40		VCAM1_HUMAN (421-768): 1.4e-26: 118: 19.44
+	Hs
		187285 SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50		VCAM1_HUMAN (421-768): 1.4e-26: 118: 19.44
+	Hs
		619714 GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69		VCAM1_HUMAN (421-768): 1.4e-26: 118: 19.44
+	Hs
		188586 SH21A_HUMAN (1-128): 5.2e-38: 126: 100.00		SIGL5_HUMAN (252-611): 1.49e-19: 95.3: 17.42
+	Hs
		258620 SH21A_HUMAN (1-128): 5.2e-38: 126: 100.00		SIGL7_HUMAN (89-316): 9.17e-17: 85.9: 29.32
+	Hs
		463561 LYN_HUMAN (1-125): 1.58e-39: 139: 19.85		SDK2_HUMAN (116-842): 5.41e-10: 65.5: 9.74
+	Hs
		619585 KSYK_HUMAN (6-120): 2.75e-15: 72.8: 25.86		VCAM1_HUMAN (421-768): 1.4e-26: 118: 19.44
+	Hs
		987544 GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69		PGBM_HUMAN (330-463): 6.39e-09: 62.4: 16.08