HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: SRMS (Q9H3Y6)
Tyrosine-protein kinase Srms (EC 2.7.10.2)
Gene: SRMS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	29568343
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 488
+	Hs
		269517 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRC_HUMAN (4-482): 0: 554: 38.95
+	Hs
		269512 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		YES_HUMAN (3-482): 0: 551: 39.06
+	Mm
		763391 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		FYN_MOUSE (7-482): 0: 550: 38.43
+	Hs
		269511 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FYN_HUMAN (7-482): 0: 550: 38.43
+	Hs
		269515 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FGR_HUMAN (1-482): 0: 544: 40.24
+	Hs
		269514 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		HCK_HUMAN (26-486): 0: 540: 40.30
+	Mm
		411926 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LCK_MOUSE (42-483): 0: 528: 42.22
+	Hs
		269510 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LCK_HUMAN (46-483): 0: 527: 42.60
+	Hs
		269519 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FRK_HUMAN (15-482): 0: 523: 40.95
+	Mm
		639444 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LYN_MOUSE (25-486): 6.96e-180: 515: 38.35
+	Hs
		269523 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		BLK_HUMAN (2-486): 5.3e-180: 515: 39.68
+	Hs
		269513 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LYN_HUMAN (1-486): 3.42e-179: 513: 36.03
+	Hs
		523046 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		SRC_HUMAN (4-482): 0: 554: 38.95
+	Hs
		412249 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		FYN_HUMAN (7-482): 0: 550: 38.43
+	Hs
		411781 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LCK_HUMAN (46-483): 0: 527: 42.60
+	Hs
		433867 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LYN_HUMAN (1-486): 3.42e-179: 513: 36.03
+	Hs
		433388 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		YES_HUMAN (3-482): 0: 551: 39.06
+	Hs
		411764 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LCK_HUMAN (46-483): 0: 527: 42.60
+	Hs
		411861 PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86		LCK_HUMAN (46-483): 0: 527: 42.60
+	Hs
		433831 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LYN_HUMAN (1-486): 3.42e-179: 513: 36.03