Interactor 1: BCAR3 (O75815)
Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Gene: BCAR3
Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.67 | 0.60 | 0.634 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25814554, unassigned1126 |
| Identification Methods | two hybrid, affinity chromatography technology, two hybrid array, luminescence based mammalian interactome mapping, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0008286 - insulin receptor signaling pathway |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
