HitPredict

Interactor 1: AP1G2 (O75843)
AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)
Gene: AP1G2

Interactor 2: AP1S3 (Q96PC3)
AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)
Gene: AP1S3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0000139 - Golgi membrane GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0030121 - AP-1 adaptor complex GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 154
+	Hs
		225791 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S2_HUMAN (2-154): 9.17e-55: 171: 71.24
+	Hs
		225794 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S1_HUMAN (1-154): 6.67e-55: 171: 67.53
+	Hs
		225849 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1S3_HUMAN (1-154): 1.65e-53: 167: 100.00
+	Hs
		225852 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP1M1_HUMAN (3-148): 1.33e-43: 150: 19.18
+	Mm
		653750 AP1G1_MOUSE (1-785): 0: 735: 58.69		AP1M1_MOUSE (3-148): 1.11e-43: 150: 19.18
+	Hs
		225845 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2M1_HUMAN (1-153): 1.25e-42: 148: 17.50
+	Hs
		225788 AP1G1_HUMAN (1-785): 0: 735: 58.81		AP2S1_HUMAN (1-142): 3.11e-45: 146: 42.96
+	Hs
		295730 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S2_HUMAN (2-154): 9.17e-55: 171: 71.24
+	Hs
		295732 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP1S1_HUMAN (1-154): 6.67e-55: 171: 67.53
+	Hs
		295757 AP1G2_HUMAN (1-785): 0: 706: 100.00		AP2M1_HUMAN (1-153): 1.25e-42: 148: 17.50
+	Rn
		614862 AP2A2_RAT (1-776): 0: 555: 24.97		AP2M1_RAT (1-153): 1.25e-42: 148: 17.50
+	Mm
		604478 AP2A2_MOUSE (1-776): 0: 556: 24.97		AP2S1_MOUSE (1-142): 3.11e-45: 146: 42.96
+	Hs
		940551 AP2B1_HUMAN (29-737): 3.37e-174: 527: 15.35		AP1S2_HUMAN (2-154): 9.17e-55: 171: 71.24
+	Hs
		965407 AP2B1_HUMAN (29-737): 3.37e-174: 527: 15.35		AP1S1_HUMAN (1-154): 6.67e-55: 171: 67.53
+	Hs
		323765 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2M1_HUMAN (1-153): 1.25e-42: 148: 17.50
+	Hs
		323690 AP2A2_HUMAN (1-776): 0: 547: 25.30		AP2S1_HUMAN (1-142): 3.11e-45: 146: 42.96
+	Ce
		773422 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		AP2M_CAEEL (1-153): 4.46e-44: 151: 18.29
+	Ce
		1166438 Q22601_CAEEL (1-764): 1.54e-178: 538: 23.88		Q19123_CAEEL (1-142): 5.09e-45: 145: 43.66
+	Sc
		763216 AP1G1_YEAST (6-775): 5.62e-177: 530: 29.43		AP1S1_YEAST (2-152): 1.28e-44: 145: 45.10
+	Hs
		922564 AP2B1_HUMAN (29-737): 3.37e-174: 527: 15.35		AP2S1_HUMAN (1-142): 3.11e-45: 146: 42.96