HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBW10 (Q5XX13)
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)
Gene: FBXW10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36990424
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Skp1~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 1052
+	Ce
		111663 G5EDD8_CAEEL (4-162): 1.85e-65: 199: 60.25		LIN23_CAEEL (259-824): 1.45e-89: 303: 16.33
+	Sc
		460737 SKP1_YEAST (2-163): 5.87e-65: 198: 42.19		CDC4_YEAST (275-702): 1.48e-88: 303: 19.87
+	Sp
		1017865 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POF1_SCHPO (276-785): 4.86e-83: 283: 21.54
+	Hs
		261394 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		TBL1X_HUMAN (514-840): 3.56e-48: 183: 11.27
+	Mm
		1353852 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBXW7_MOUSE (559-835): 1.7e-42: 168: 14.15
+	Hs
		992290 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBXW7_HUMAN (559-835): 2.82e-42: 167: 13.82
+	Sp
		1068653 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POF11_SCHPO (504-759): 1.51e-38: 153: 18.70
+	Mm
		1190510 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBW1A_MOUSE (10-448): 9.82e-23: 106: 10.64
+	Xl
		1259301 SKP1_XENLA (1-163): 1.63e-87: 254: 100.00		TRCB_XENLA (10-442): 4.22e-23: 106: 10.22
+	Ce
		111145 SKR1_CAEEL (4-162): 2.26e-78: 232: 70.81		SEL10_CAEEL (608-835): 1.65e-27: 121: 7.86
+	Dm
		305542 O77430_DROME (1-163): 1.01e-79: 235: 76.69		FBXW7_DROME (148-476): 4.85e-26: 118: 10.03
+	Sc
		809273 SKP1_YEAST (2-163): 5.87e-65: 198: 42.19		MET30_YEAST (5-483): 6.66e-38: 153: 12.35
+	Hs
		992399 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBW1A_HUMAN (602-761): 5.89e-17: 87.6: 10.63
+	Dm
		232056 O77430_DROME (1-163): 1.01e-79: 235: 76.69		O44382_DROME (131-452): 8.65e-23: 105: 10.91
+	Mm
		1210439 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBW1B_MOUSE (602-686): 2.36e-13: 76: 16.47
+	Hs
		992384 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBW1B_HUMAN (602-686): 5.1e-13: 74.8: 16.47
+	Dm
		305505 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VDE3_DROME (613-686): 1.32e-12: 73.7: 13.51
+	Dm
		1267182 Q7KJ69_DROME (1-163): 1.93e-74: 221: 67.49		Q9VDE3_DROME (613-686): 1.32e-12: 73.7: 13.51
+	Sp
		153337 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POP2_SCHPO (451-610): 2.75e-10: 66.6: 28.05
+	Dm
		1471477 Q9VWC4_DROME (2-153): 3.69e-64: 195: 56.21		Q9VDE3_DROME (613-686): 1.32e-12: 73.7: 13.51