HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.770

The method score is based on:

Property Details
Experiments 24366813, 25283809, 25796446, 27325643, 27684187, 29891922, 30472188, 31619268, 32292505, 26933062, 35210364, 35044719, 36640330, 38280479, 38223760, 18413746, 21041411, 18158288, 17889669, 18640976 and 18 others

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Identification Methods affinity chromatography technology, pull down, unspecified method, proximity labelling technology, enzymatic study, protein complementation assay, tandem affinity purification, protein kinase assay, isothermal titration calorimetry, phage display and 1 others

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Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0030216 - keratinocyte differentiation
GO:0035329 - hippo signaling
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1130
Hs

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Last updated: 15 Jul 2024