HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	24107629, 34079125, 21212414, 21383157, 28416659, 23564455
Identification Methods	unspecified method, proximity labelling technology, affinity chromatography technology, pull down, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 903
+	Hs
		325886 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125071 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		325655 LATS1_HUMAN (1-1130): 0: 934: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808286 LATS2_HUMAN (13-1121): 0: 751: 49.61		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		568765 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1299664 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		681988 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		325898 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		325894 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Hs
		808324 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		681731 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1336122 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1069657 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Dm
		1360297 WARTS_DROME (161-1065): 1.96e-152: 486: 39.48		SMUF1_DROME (16-518): 1.15e-39: 161: 16.19
+	Hs
		1035209 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71