HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20159774
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 758
+	Hs
		529186 AKT2_HUMAN (62-535): 6.3e-140: 414: 23.08		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529185 AKT1_HUMAN (62-535): 1.24e-137: 409: 21.58		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529023 KPCA_HUMAN (44-542): 4.62e-131: 398: 20.71		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		436592 KPCB_HUMAN (44-535): 2.82e-130: 396: 20.80		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529026 KAPCA_HUMAN (178-537): 1.69e-129: 383: 29.24		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529085 KAPCB_HUMAN (178-537): 5.07e-129: 382: 28.96		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		96829 E9PBG7_HUMAN (215-486): 3.74e-123: 373: 37.59		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Hs
		529756 KCC2D_HUMAN (215-486): 3.56e-122: 369: 37.96		TAU_HUMAN (1-758): 6.41e-90: 300: 100.00
+	Rn
		620044 KPCB_RAT (44-535): 1.39e-129: 394: 20.60		TAU_RAT (1-758): 3.21e-76: 263: 72.11
+	Rn
		98735 KPCB_RAT (44-535): 1.39e-129: 394: 20.60		F1LST4_RAT (1-757): 7.75e-76: 262: 72.21
+	Rn
		620042 KAPCB_RAT (178-537): 1.99e-128: 380: 28.42		TAU_RAT (1-758): 3.21e-76: 263: 72.11
+	Rn
		98733 KAPCB_RAT (178-537): 1.99e-128: 380: 28.42		F1LST4_RAT (1-757): 7.75e-76: 262: 72.21
+	Mm
		424696 KAPCA_MOUSE (178-537): 7.89e-128: 379: 28.96		TAU_MOUSE (1-758): 8.57e-72: 250: 70.17
+	Hs
		354979 CHK2_HUMAN (1-543): 5.4e-175: 506: 100.00		MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48
+	Hs
		355022 CHK2_HUMAN (1-543): 5.4e-175: 506: 100.00		CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46
+	Hs
		536312 KAPCA_HUMAN (178-537): 1.69e-129: 383: 29.24		MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42
+	Hs
		536315 KAPCB_HUMAN (178-537): 5.07e-129: 382: 28.96		MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42
+	Mm
		631789 KCC2D_MOUSE (215-486): 3.56e-122: 369: 37.96		MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41
+	Hs
		161418 AKT1_HUMAN (62-535): 1.24e-137: 409: 21.58		KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76
+	Bt
		362104 KAPCA_BOVIN (178-537): 3.28e-128: 380: 29.24		TAU_BOVIN (1-310): 1.54e-11: 69.3: 36.22