HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PHD, Histone~PWWP, Histone~SET
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 140
+	Hs
		355489 NSD2_HUMAN (1-1365): 0: 988: 100.00		H31_HUMAN (5-134): 1.3e-52: 164: 48.86
+	Hs
		355534 NSD2_HUMAN (1-1365): 0: 988: 100.00		H31T_HUMAN (5-134): 1.02e-51: 162: 48.09
+	Hs
		355497 NSD2_HUMAN (1-1365): 0: 988: 100.00		H33_HUMAN (5-134): 1.58e-51: 161: 49.62
+	Hs
		355545 NSD2_HUMAN (1-1365): 0: 988: 100.00		H32_HUMAN (5-134): 1.74e-51: 161: 48.86
+	Hs
		883678 NSD3_HUMAN (116-1340): 0: 764: 45.27		CENPA_HUMAN (1-140): 2.14e-55: 171: 100.00
+	Hs
		998773 NSD3_HUMAN (116-1340): 0: 764: 45.27		H31_HUMAN (5-134): 1.3e-52: 164: 48.86
+	Hs
		1162034 NSD3_HUMAN (116-1340): 0: 764: 45.27		H31T_HUMAN (5-134): 1.02e-51: 162: 48.09
+	Hs
		1239475 NSD3_HUMAN (116-1340): 0: 764: 45.27		H3C_HUMAN (5-134): 5.17e-52: 162: 47.69
+	Hs
		1017187 NSD3_HUMAN (116-1340): 0: 764: 45.27		H33_HUMAN (5-134): 1.58e-51: 161: 49.62
+	Hs
		216410 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H31_HUMAN (5-134): 1.3e-52: 164: 48.86
+	Hs
		216462 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H3C_HUMAN (5-134): 5.17e-52: 162: 47.69
+	Hs
		216415 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H33_HUMAN (5-134): 1.58e-51: 161: 49.62
+	Hs
		216473 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H32_HUMAN (5-134): 1.74e-51: 161: 48.86
+	Hs
		998807 SUV92_HUMAN (826-1203): 1.91e-73: 252: 20.84		H31_HUMAN (5-134): 1.3e-52: 164: 48.86
+	Hs
		1017210 SUV92_HUMAN (826-1203): 1.91e-73: 252: 20.84		H33_HUMAN (5-134): 1.58e-51: 161: 49.62
+	Dm
		381741 ASH1_DROME (991-1237): 9.71e-67: 251: 37.65		H3_DROME (5-134): 1.74e-51: 161: 48.86
+	Hs
		216457 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H37_HUMAN (5-134): 1.19e-49: 156: 47.33
+	Hs
		998846 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		H31_HUMAN (5-134): 1.3e-52: 164: 48.86
+	Sc
		805564 SET1_YEAST (995-1203): 5.02e-62: 233: 31.11		H3_YEAST (5-134): 5.28e-46: 147: 46.57
+	Sc
		863938 SET2_YEAST (972-1208): 1.23e-61: 227: 35.12		H3_YEAST (5-134): 5.28e-46: 147: 46.57