HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36089195, 29044188
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PHD, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 136
+	Hs
		355489 NSD2_HUMAN (1-1365): 0: 988: 100.00		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		355534 NSD2_HUMAN (1-1365): 0: 988: 100.00		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		355545 NSD2_HUMAN (1-1365): 0: 988: 100.00		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		355456 NSD2_HUMAN (1-1365): 0: 988: 100.00		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Hs
		998773 NSD3_HUMAN (116-1340): 0: 764: 45.27		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1017187 NSD3_HUMAN (116-1340): 0: 764: 45.27		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1162034 NSD3_HUMAN (116-1340): 0: 764: 45.27		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		1239475 NSD3_HUMAN (116-1340): 0: 764: 45.27		H3C_HUMAN (1-136): 2e-56: 173: 95.59
+	Hs
		883678 NSD3_HUMAN (116-1340): 0: 764: 45.27		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Hs
		216410 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		216415 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		216473 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		998807 SUV92_HUMAN (826-1203): 1.91e-73: 252: 20.84		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1017210 SUV92_HUMAN (826-1203): 1.91e-73: 252: 20.84		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Dm
		381741 ASH1_DROME (991-1237): 9.71e-67: 251: 37.65		H3_DROME (1-136): 5.34e-59: 180: 97.06
+	Hs
		216457 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H37_HUMAN (1-136): 4.56e-57: 175: 94.12
+	Hs
		216462 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		H3C_HUMAN (1-136): 2e-56: 173: 95.59
+	Hs
		998846 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Sc
		805564 SET1_YEAST (995-1203): 5.02e-62: 233: 31.11		H3_YEAST (1-136): 3.63e-54: 168: 90.44
+	Sc
		863938 SET2_YEAST (972-1208): 1.23e-61: 227: 35.12		H3_YEAST (1-136): 3.63e-54: 168: 90.44