HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: ANKR6 (Q9Y2G4)
Ankyrin repeat domain-containing protein 6 (Diversin)
Gene: ANKRD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	35914814
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank~Ank_4, Ank_2~Ank_4, Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 727
+	Hs
		1330891 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ANKR6_HUMAN (1-727): 1.29e-163: 491: 100.00
+	Hs
		883555 RIPK4_HUMAN (1-832): 0: 726: 100.00		MIB1_HUMAN (1-431): 4.37e-67: 241: 21.24
+	Hs
		883496 RIPK4_HUMAN (1-832): 0: 726: 100.00		ANK3_HUMAN (82-631): 8.14e-61: 224: 15.58
+	Hs
		1206048 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		MIB1_HUMAN (1-431): 4.37e-67: 241: 21.24
+	Hs
		1021462 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ANK3_HUMAN (82-631): 8.14e-61: 224: 15.58
+	Hs
		883691 RIPK4_HUMAN (1-832): 0: 726: 100.00		ASB3_HUMAN (147-308): 2.51e-28: 121: 27.55
+	Hs
		883487 RIPK4_HUMAN (1-832): 0: 726: 100.00		ANK2_HUMAN (2-127): 5.88e-27: 120: 29.13
+	Hs
		1330905 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ASB3_HUMAN (147-308): 2.51e-28: 121: 27.55
+	Hs
		965154 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ANK2_HUMAN (2-127): 5.88e-27: 120: 29.13
+	Hs
		883460 RIPK4_HUMAN (1-832): 0: 726: 100.00		RIPK4_HUMAN (166-267): 2.76e-13: 75.5: 21.57
+	Hs
		1330845 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		Q9H4D1_HUMAN (166-267): 3.16e-13: 75.5: 21.57
+	Mm
		1322330 RIPK4_MOUSE (1-832): 0: 695: 82.81		RIPK4_MOUSE (166-267): 4.17e-12: 71.7: 19.61
+	Hs
		1329533 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		TNKS2_HUMAN (1-608): 1.49e-77: 272: 16.98
+	Hs
		862012 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		DAPK1_HUMAN (1-333): 5.52e-74: 263: 24.04
+	Hs
		862070 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		MIB1_HUMAN (1-431): 4.37e-67: 241: 21.24
+	Hs
		167036 ANR50_HUMAN (353-788): 9.53e-101: 343: 24.36		ANR28_HUMAN (5-167): 8.1e-33: 138: 25.44
+	Hs
		167014 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		ANR28_HUMAN (5-167): 8.1e-33: 138: 25.44
+	Hs
		862028 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		ANK2_HUMAN (2-127): 5.88e-27: 120: 29.13
+	Hs
		166913 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		ANR28_HUMAN (5-167): 8.1e-33: 138: 25.44