HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31248990, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 2115
+	Hs
		355527 NSD2_HUMAN (1-1365): 0: 988: 100.00		PLEC_HUMAN (628-2114): 9.11e-27: 122: 10.00
+	Hs
		216439 SUV91_HUMAN (830-1202): 3.1e-74: 255: 20.52		NUMA1_HUMAN (1-2115): 3.94e-159: 544: 100.00
+	Hs
		1134727 SUV92_HUMAN (826-1203): 1.91e-73: 252: 20.84		NUMA1_HUMAN (1-2115): 3.94e-159: 544: 100.00
+	Hs
		1134594 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		NUMA1_HUMAN (1-2115): 3.94e-159: 544: 100.00
+	Hs
		1134730 EHMT1_HUMAN (906-1224): 5.89e-56: 215: 21.43		NUMA1_HUMAN (1-2115): 3.94e-159: 544: 100.00
+	Hs
		1041526 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		NUMA1_HUMAN (1-2115): 3.94e-159: 544: 100.00
+	Hs
		176988 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		CE290_HUMAN (257-2069): 1.44e-48: 194: 12.21
+	Hs
		772823 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		MYH9_HUMAN (1033-1891): 1.2e-33: 145: 10.62
+	Hs
		773192 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		MYH10_HUMAN (1257-2089): 8.04e-33: 142: 11.87
+	Hs
		1105614 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		GOGA4_HUMAN (921-2109): 5.83e-32: 139: 9.75
+	Hs
		883943 SETD2_HUMAN (852-1238): 1.68e-54: 212: 27.74		CENPF_HUMAN (1-781): 2.3e-32: 141: 12.77
+	Hs
		1143278 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		PLEC_HUMAN (628-2114): 9.11e-27: 122: 10.00
+	Hs
		1143130 EZH2_HUMAN (904-1188): 5.22e-59: 220: 22.48		PLEC_HUMAN (628-2114): 9.11e-27: 122: 10.00
+	Hs
		1141960 ASH1L_HUMAN (924-1232): 1.68e-58: 225: 31.75		EEA1_HUMAN (70-766): 2.58e-24: 114: 15.40
+	Hs
		563050 KMT2A_HUMAN (1049-1203): 7.33e-42: 171: 32.05		MYH8_HUMAN (1083-2115): 4.32e-37: 156: 10.06
+	Mm
		1231081 Q6AXH7_MOUSE (904-1188): 1.19e-58: 218: 22.48		PLEC_MOUSE (1-508): 1.18e-14: 82.7: 8.84