HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: NR3L1 (Q68D85)
Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)
Gene: NCR3LG1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~Furin-like, C1-set~GF_recep_IV, C1-set~Recep_L_domain
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 454
+	Hs
		410899 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NR3L1_HUMAN (1-454): 7.39e-145: 423: 100.00
+	Hs
		363659 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NECT2_HUMAN (21-261): 2.05e-31: 128: 20.23
+	Hs
		363257 EGFR_HUMAN (1-1210): 0: 1246: 100.00		CD166_HUMAN (16-259): 3.07e-30: 125: 15.60
+	Hs
		363993 EGFR_HUMAN (1-1210): 0: 1246: 100.00		BTNL2_HUMAN (32-275): 1.38e-23: 105: 16.67
+	Hs
		362680 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NCAM1_HUMAN (13-299): 1e-13: 75.5: 12.03
+	Hs
		410976 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NECT2_HUMAN (21-261): 2.05e-31: 128: 20.23
+	Hs
		410828 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		CD166_HUMAN (16-259): 3.07e-30: 125: 15.60
+	Hs
		410853 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		OPCM_HUMAN (21-282): 3.29e-16: 81.6: 13.43
+	Hs
		580772 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		PVR_HUMAN (18-261): 3.11e-32: 128: 23.29
+	Hs
		137374 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		BT3A3_HUMAN (7-320): 2.29e-31: 128: 16.31
+	Hs
		710404 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		NECT2_HUMAN (21-261): 2.05e-31: 128: 20.23
+	Hs
		710247 EPHA2_HUMAN (665-1016): 2.96e-113: 379: 32.79		OPCM_HUMAN (21-282): 3.29e-16: 81.6: 13.43
+	Rn
		47611 INSR_RAT (579-1032): 3.03e-104: 361: 23.87		A0A8I5Y130_RAT (1-146): 2.64e-22: 94.5: 14.47
+	Hs
		465484 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		SHPS1_HUMAN (50-276): 3.27e-14: 76.5: 16.39
+	Hs
		564802 EPHA3_HUMAN (654-981): 2.3e-111: 374: 34.81		NCAM1_HUMAN (13-299): 1e-13: 75.5: 12.03
+	Mm
		1021901 FAK2_MOUSE (716-974): 4.24e-52: 201: 37.64		SHPS1_MOUSE (18-264): 5.8e-31: 126: 18.46
+	Hs
		128551 KSYK_HUMAN (716-961): 1.14e-53: 201: 41.70		SIRB1_HUMAN (50-288): 1.6e-14: 76.9: 14.84
+	Hs
		439874 INSR_HUMAN (336-637): 2.63e-27: 122: 21.64		BTNL2_HUMAN (32-275): 1.38e-23: 105: 16.67