HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DOK5 (Q9P104)
Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
Gene: DOK5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030182 - neuron differentiation GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 306
+	Hs
		363438 EGFR_HUMAN (1-1210): 0: 1246: 100.00		DOK6_HUMAN (1-306): 2.1e-126: 365: 70.13
+	Hs
		363610 EGFR_HUMAN (1-1210): 0: 1246: 100.00		DOK4_HUMAN (1-298): 9.33e-119: 346: 60.33
+	Mm
		267118 EGFR_MOUSE (1-1210): 0: 1267: 90.35		DOK2_MOUSE (6-292): 1.39e-75: 238: 20.85
+	Hs
		249705 EGFR_HUMAN (1-1210): 0: 1246: 100.00		DOK2_HUMAN (6-268): 2.64e-76: 240: 22.42
+	Hs
		410906 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		DOK6_HUMAN (1-306): 2.1e-126: 365: 70.13
+	Hs
		363765 EGFR_HUMAN (1-1210): 0: 1246: 100.00		DOK1_HUMAN (6-264): 5.21e-72: 231: 22.59
+	Hs
		410959 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		DOK4_HUMAN (1-298): 9.33e-119: 346: 60.33
+	Hs
		364079 EGFR_HUMAN (1-1210): 0: 1246: 100.00		IRS2_HUMAN (8-304): 5.42e-63: 217: 17.01
+	Hs
		363484 EGFR_HUMAN (1-1210): 0: 1246: 100.00		DOK3_HUMAN (9-267): 4.72e-65: 213: 19.73
+	Hs
		362878 EGFR_HUMAN (1-1210): 0: 1246: 100.00		IRS1_HUMAN (2-304): 2.2e-61: 212: 19.34
+	Hs
		160382 EGFR_HUMAN (1-1210): 0: 1246: 100.00		IRS4_HUMAN (6-234): 5.17e-54: 191: 19.47
+	Hs
		363617 EGFR_HUMAN (1-1210): 0: 1246: 100.00		FRS2_HUMAN (129-263): 9.34e-29: 116: 21.92
+	Hs
		411019 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		DOK1_HUMAN (6-264): 5.21e-72: 231: 22.59
+	Hs
		410668 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		IRS1_HUMAN (2-304): 2.2e-61: 212: 19.34
+	Hs
		160389 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		IRS4_HUMAN (6-234): 5.17e-54: 191: 19.47
+	Hs
		220216 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		FRS3_HUMAN (126-303): 7.1e-42: 152: 20.79
+	Hs
		463988 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		DOK6_HUMAN (1-306): 2.1e-126: 365: 70.13
+	Hs
		464017 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		DOK4_HUMAN (1-298): 9.33e-119: 346: 60.33
+	Hs
		249712 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		DOK2_HUMAN (6-268): 2.64e-76: 240: 22.42
+	Hs
		464018 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		FRS2_HUMAN (129-263): 9.34e-29: 116: 21.92