HitPredict

Interactor 1: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Interactor 2: EGFR (Q01279)
Epidermal growth factor receptor (EC 2.7.10.1)
Gene: EGFR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15831486
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 1210
+	Hs
		249705 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		363765 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		363484 DOK3_HUMAN (6-389): 6.68e-101: 310: 32.30		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		362878 IRS1_HUMAN (4-375): 4.24e-89: 294: 16.03		EGFR_HUMAN (1-1210): 0: 1228: 90.35
+	Hs
		411019 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ERBB2_HUMAN (7-1203): 0: 1110: 48.34
+	Mm
		267113 DOK2_MOUSE (1-412): 1.12e-159: 457: 100.00		ABL1_MOUSE (689-1180): 8.19e-119: 397: 26.64
+	Hs
		249712 DOK2_HUMAN (4-412): 4.99e-142: 412: 74.04		RET_HUMAN (433-1084): 1.43e-132: 435: 23.09
+	Hs
		464042 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		RET_HUMAN (433-1084): 1.43e-132: 435: 23.09
+	Mm
		362440 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		ABL1_MOUSE (689-1180): 8.19e-119: 397: 26.64
+	Mm
		362456 DOK3_MOUSE (6-389): 1.3e-103: 315: 32.23		ABL1_MOUSE (689-1180): 8.19e-119: 397: 26.64
+	Mm
		581958 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		INSR_MOUSE (643-1034): 6.16e-103: 357: 24.81
+	Mm
		581969 DOK3_MOUSE (6-389): 1.3e-103: 315: 32.23		INSR_MOUSE (643-1034): 6.16e-103: 357: 24.81
+	Mm
		772552 IRS1_MOUSE (4-375): 3.65e-90: 297: 16.24		EPHA2_MOUSE (676-997): 1.43e-110: 372: 35.98
+	Mm
		581954 IRS1_MOUSE (4-375): 3.65e-90: 297: 16.24		INSR_MOUSE (643-1034): 6.16e-103: 357: 24.81
+	Mm
		1021487 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		FAK2_MOUSE (718-976): 3.25e-53: 205: 38.40
+	Hs
		840979 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		ABL2_HUMAN (709-976): 1.96e-52: 203: 40.74
+	Mm
		869538 DOK1_MOUSE (6-393): 3.96e-113: 341: 34.51		KSYK_MOUSE (720-976): 1.72e-52: 197: 40.31
+	Hs
		439838 DOK1_HUMAN (6-394): 5.34e-111: 336: 34.11		INSR_HUMAN (354-658): 5.7e-17: 89.1: 20.68
+	Mm
		772558 IRS1_MOUSE (4-375): 3.65e-90: 297: 16.24		IGF1R_MOUSE (356-641): 4.24e-21: 102: 24.07
+	Rn
		580450 IRS1_RAT (4-375): 5.83e-91: 300: 16.24		INSR_RAT (354-658): 7.94e-17: 88.7: 21.53