HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: EPHA8 (P29322)
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Gene: EPHA8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10498895
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0030425 - dendrite GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 1005
+	Hs
		412104 FYN_HUMAN (1-537): 0: 643: 100.00		EPHA5_HUMAN (2-1001): 0: 1242: 57.21
+	Hs
		412105 FYN_HUMAN (1-537): 0: 643: 100.00		EPHA4_HUMAN (8-1005): 0: 1220: 55.92
+	Mm
		763386 FYN_MOUSE (1-537): 0: 642: 99.44		EPHA4_MOUSE (8-1005): 0: 1217: 55.72
+	Hs
		412036 FYN_HUMAN (1-537): 0: 643: 100.00		EPHA3_HUMAN (24-1001): 0: 1208: 55.66
+	Hs
		522871 SRC_HUMAN (1-537): 0: 598: 68.21		EPHA4_HUMAN (8-1005): 0: 1220: 55.92
+	Mm
		403425 SRC_MOUSE (1-537): 0: 599: 68.33		EPHB2_MOUSE (31-999): 0: 1212: 50.56
+	Hs
		522803 SRC_HUMAN (1-537): 0: 598: 68.21		EPHB2_HUMAN (31-1005): 0: 1211: 49.95
+	Hs
		522802 SRC_HUMAN (1-537): 0: 598: 68.21		EPHA3_HUMAN (24-1001): 0: 1208: 55.66
+	Hs
		412103 FYN_HUMAN (1-537): 0: 643: 100.00		EPHB3_HUMAN (26-998): 0: 1141: 49.75
+	Hs
		412007 FYN_HUMAN (1-537): 0: 643: 100.00		EPHA1_HUMAN (7-993): 0: 1017: 40.18
+	Hs
		522808 SRC_HUMAN (1-537): 0: 598: 68.21		UFO_HUMAN (264-981): 3.57e-161: 499: 22.34
+	Hs
		522932 SRC_HUMAN (1-537): 0: 598: 68.21		TYRO3_HUMAN (264-987): 2.51e-149: 468: 21.12
+	Hs
		412143 FYN_HUMAN (1-537): 0: 643: 100.00		FAK1_HUMAN (612-901): 4.66e-59: 222: 41.03
+	Hs
		411936 FYN_HUMAN (1-537): 0: 643: 100.00		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Hs
		522927 SRC_HUMAN (1-537): 0: 598: 68.21		FAK1_HUMAN (612-901): 4.66e-59: 222: 41.03
+	Hs
		433546 SRC_HUMAN (1-537): 0: 598: 68.21		LYN_HUMAN (629-900): 2.17e-59: 214: 41.39
+	Hs
		111147 YES_HUMAN (1-537): 0: 591: 71.61		I6L996_HUMAN (612-901): 3.61e-60: 220: 41.03
+	Hs
		411969 SRC_HUMAN (1-537): 0: 598: 68.21		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Hs
		433216 YES_HUMAN (1-537): 0: 591: 71.61		LYN_HUMAN (629-900): 2.17e-59: 214: 41.39
+	Hs
		411946 YES_HUMAN (1-537): 0: 591: 71.61		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76