HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: RPKL1 (Q9Y6S9)
Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1)
Gene: RPS6KL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 549
+	Hs
		431965 HS90A_HUMAN (1-732): 0: 1087: 100.00		PKN3_HUMAN (3-549): 5.4e-128: 397: 18.75
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (190-548): 5.78e-126: 379: 19.79
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (190-547): 1.61e-123: 373: 18.98
+	Hs
		431510 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCA_HUMAN (92-548): 2.53e-119: 368: 17.01
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (285-547): 6.88e-119: 356: 21.09
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (285-547): 6.88e-119: 356: 21.09
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (285-547): 1.84e-118: 355: 20.73
+	Hs
		431537 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCG_HUMAN (286-547): 3.18e-117: 352: 20.80
+	Hs
		431674 HS90A_HUMAN (1-732): 0: 1087: 100.00		PRKX_HUMAN (271-547): 2.58e-105: 321: 22.55
+	Hs
		431621 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCI_HUMAN (267-545): 1.23e-91: 294: 21.36
+	Hs
		431766 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCZ_HUMAN (249-548): 4.13e-83: 271: 21.99
+	Hs
		431752 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCE_HUMAN (223-548): 1.89e-79: 265: 21.10
+	Hs
		408527 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCB_HUMAN (345-547): 9.81e-78: 259: 28.18
+	Hs
		431542 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B1_HUMAN (380-549): 3e-79: 259: 33.89
+	Hs
		431672 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A3_HUMAN (201-547): 1.1e-72: 247: 16.88
+	Hs
		431873 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A2_HUMAN (201-538): 1.24e-69: 239: 15.63
+	Hs
		431876 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A1_HUMAN (380-538): 6.51e-40: 156: 25.84
+	Hs
		431767 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCD_HUMAN (392-547): 1.88e-22: 103: 35.93
+	Hs
		270363 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A5_HUMAN (386-547): 4.48e-21: 99.4: 35.75
+	Hs
		431762 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCT_HUMAN (392-547): 4.49e-21: 99.4: 34.94