HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 15731013, 34079125, 28524877, 39358380, 31839598, 32296183, 30021884, 9630597, 37071682, 35575683, 39422127, 21988832, 8576158, 10954706, 11684708, unassigned1304, 14756564, 10852826
Identification Methods pull down, proximity labelling technology, cross-linking study, two hybrid, cosedimentation, two hybrid prey pooling approach, two hybrid array, biophysical, validated two hybrid, cosedimentation in solution
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Filament~Filament
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0016363 - nuclear matrix
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 11Aug2025