HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: K1C19 (P08727)
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Gene: KRT19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.955

The method score is based on:

Property Details
Experiments 32296183, 34079125, 35575683, 39358380, 31839598, 39422127, unassigned1304
Identification Methods two hybrid, proximity labelling technology, cross-linking study, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Filament~Filament
Common GO terms GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0016327 - apicolateral plasma membrane
GO:0030018 - Z disc
GO:0042383 - sarcolemma
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 11Aug2025