HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 470
+	Hs
		475684 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		129527 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Hs
		476627 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		475691 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (9-286): 3.93e-44: 163: 14.84
+	Hs
		475842 UBC_HUMAN (1-685): 0: 846: 100.00		RN151_HUMAN (3-163): 4.17e-38: 140: 26.38
+	Hs
		476160 UBC_HUMAN (1-685): 0: 846: 100.00		RN166_HUMAN (9-146): 3.64e-16: 79.5: 25.90
+	Mm
		476826 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		TRAF4_MOUSE (1-470): 1.84e-120: 362: 96.81
+	Rn
		78208 UBC_RAT (1-108): 1.27e-29: 127: 90.74		B5DFH7_RAT (2-465): 1.09e-113: 345: 30.24
+	Hs
		397944 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		475011 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Rn
		88507 UBC_RAT (1-108): 1.27e-29: 127: 90.74		D3Z9G0_RAT (3-465): 4.94e-101: 315: 24.17
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86
+	Hs
		924227 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		301744 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI37_HUMAN (5-465): 5.48e-55: 199: 13.81
+	Hs
		475013 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	At
		1091851 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q8W1E7_ARATH (80-231): 4.23e-12: 70.3: 22.88
+	Mm
		924236 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86
+	Hs
		924180 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		ZNF71_HUMAN (4-216): 4.29e-41: 154: 13.95
+	Mm
		476831 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86