HitPredict

Interactor 1: CDC7 (P06243)
Cell division control protein 7 (EC 2.7.11.1)
Gene: CDC7

Interactor 2: MCM4 (P30665)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)
Gene: MCM4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	17018296, 38776358, 24566989, 9407029, 10508166, 25319829, 23549044, 34963704, 19270162, 21070963, 24234446
Identification Methods	pull down, affinity chromatography technology, enzymatic study, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006270 - DNA replication initiation and 1 others more... GO:0006279 - premeiotic DNA replication
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 507 Sc			1 933
+	Sc
		440957 CDC7_YEAST (1-507): 5.8e-131: 391: 100.00		MCM6_YEAST (106-930): 0: 696: 23.84
+	Sc
		440910 CDC7_YEAST (1-507): 5.8e-131: 391: 100.00		MCM5_YEAST (189-905): 0: 679: 26.92
+	Sp
		712715 HSK1_SCHPO (6-496): 4.32e-85: 273: 35.95		MCM4_SCHPO (42-928): 0: 796: 56.44
+	Sc
		440909 CDC7_YEAST (1-507): 5.8e-131: 391: 100.00		MCM2_YEAST (23-849): 0: 677: 25.49
+	Hs
		667580 CDK2_HUMAN (31-324): 4.88e-62: 206: 20.59		MCM4_HUMAN (30-926): 0: 826: 41.57
+	Xl
		939256 Q9PWM7_XENLA (17-473): 9.23e-94: 295: 27.46		MCM2_XENLA (52-902): 0: 715: 27.47
+	Hs
		887878 SIK1_HUMAN (24-494): 2.27e-81: 270: 13.82		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Dm
		1176040 CDC7_DROME (16-187): 4.74e-48: 178: 33.72		MCM4_DROME (35-926): 0: 794: 40.24
+	Hs
		132438 CDC7_HUMAN (270-473): 2.18e-34: 138: 26.39		MCM4_HUMAN (30-926): 0: 826: 41.57
+	Sp
		823547 HSK1_SCHPO (6-496): 4.32e-85: 273: 35.95		MCM2_SCHPO (80-851): 0: 663: 27.16
+	Hs
		667649 CDK2_HUMAN (31-324): 4.88e-62: 206: 20.59		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Hs
		667851 CDK2_HUMAN (31-324): 4.88e-62: 206: 20.59		MCM6_HUMAN (170-909): 0: 696: 27.72
+	Dm
		887832 CDC7_DROME (16-187): 4.74e-48: 178: 33.72		MCM2_DROME (30-908): 0: 722: 26.14
+	Hs
		132448 CDC7_HUMAN (270-473): 2.18e-34: 138: 26.39		MCM2_HUMAN (31-902): 0: 714: 26.03
+	Hs
		667581 CDK2_HUMAN (31-324): 4.88e-62: 206: 20.59		MCM7_HUMAN (186-904): 0: 646: 29.50
+	Hs
		132439 CDC7_HUMAN (270-473): 2.18e-34: 138: 26.39		MCM5_HUMAN (155-909): 0: 703: 28.42
+	Hs
		132477 CDC7_HUMAN (270-473): 2.18e-34: 138: 26.39		MCM6_HUMAN (170-909): 0: 696: 27.72
+	Hs
		132440 CDC7_HUMAN (270-473): 2.18e-34: 138: 26.39		MCM7_HUMAN (186-904): 0: 646: 29.50
+	Sc
		602353 PHO85_YEAST (236-471): 6.86e-15: 77.2: 17.80		MCM2_YEAST (23-849): 0: 677: 25.49
+	Sc
		440929 CDC7_YEAST (1-507): 5.8e-131: 391: 100.00		MCM7_YEAST (314-863): 6.75e-96: 322: 39.04