Protein: CDC7
Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)

Gene: CDC7
Organism: Homo sapiens
Interactions: 127
UniProt ID: O00311

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000727 - double-strand break repair via break-induced replication
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132524

DBF4A
Protein DBF4 homolog A

15

5

Small-scale

0.987

High

132500

DBF4B
Protein DBF4 homolog B

5

5

Small-scale

0.919

High

132434

CDK2
Cyclin-dependent kinase 2

2

19

Small-scale

0.812

High

132472

IKZF1
DNA-binding protein Ikaros

2

6

High-throughput

0.783

High

132510

IKZF4
Zinc finger protein Eos

2

7

High-throughput

0.783

High

132517

ZBT26
Zinc finger and BTB domain-containing protein 26

2

2

High-throughput

0.783

High

132526

IKZF3
Zinc finger protein Aiolos

2

5

High-throughput

0.783

High

132448

MCM2
DNA replication licensing factor MCM2

10

19

Small-scale

0.753

High

132452

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.698

High

132427

CDK4
Cyclin-dependent kinase 4

1

18

High-throughput

0.692

High

132441

CDN1A
Cyclin-dependent kinase inhibitor 1

1

12

High-throughput

0.692

High

132431

CSK22
Casein kinase II subunit alpha'

1

20

High-throughput

0.691

High

132443

CETN2
Centrin-2

1

17

High-throughput

0.691

High

132450

CDK7
Cyclin-dependent kinase 7

1

19

High-throughput

0.691

High

132454

CCNH
Cyclin-H

1

20

High-throughput

0.691

High

132455

MAT1
CDK-activating kinase assembly factor MAT1

1

1

High-throughput

0.691

High

132457

RD23B
UV excision repair protein RAD23 homolog B

1

11

High-throughput

0.691

High

132480

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.691

High

132532

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

9

High-throughput

0.691

High

132514

CLSPN
Claspin

3

5

Small-scale

0.680

High

132438

MCM4
DNA replication licensing factor MCM4

3

17

Small-scale

0.650

High

132440

MCM7
DNA replication licensing factor MCM7

3

19

Small-scale

0.650

High

132409

CDC7
Cell division cycle 7-related protein kinase

1

17

Small-scale

0.647

High

132435

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.619

High

65291

RFOX3
RNA binding protein fox-1 homolog 3

1

7

High-throughput

0.618

High

132413

RFOX2
RNA binding protein fox-1 homolog 2

1

8

High-throughput

0.618

High

132442

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

132511

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

13

High-throughput

0.618

High

132512

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

132521

RFOX1
RNA binding protein fox-1 homolog 1

1

9

High-throughput

0.618

High

132528

CILK1
Serine/threonine-protein kinase ICK

1

19

Small-scale

0.618

High

132418

STAM2
Signal transducing adapter molecule 2

2

7

High-throughput

0.606

High

132419

TRI37
E3 ubiquitin-protein ligase TRIM37

2

20

High-throughput

0.606

High

132428

TRI27
Zinc finger protein RFP

2

10

High-throughput

0.606

High

132453

FXR1
RNA-binding protein FXR1

2

8

High-throughput

0.606

High

132466

GOGA2
Golgin subfamily A member 2

2

20

High-throughput

0.606

High

132470

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

18

High-throughput

0.606

High

132484

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

20

High-throughput

0.606

High

132487

HMBX1
Homeobox-containing protein 1

2

5

High-throughput

0.606

High

132496

BANP
Protein BANP

2

1

High-throughput

0.606

High

132497

ZBT8B
Zinc finger and BTB domain-containing protein 8B

2

4

High-throughput

0.606

High

132505

ZBT10
Zinc finger and BTB domain-containing protein 10

2

7

High-throughput

0.606

High

132525

GMEB2
Glucocorticoid modulatory element-binding protein 2

2

1

High-throughput

0.606

High

132529

LZTS1
Leucine zipper putative tumor suppressor 1

2

20

High-throughput

0.606

High

132477

MCM6
DNA replication licensing factor MCM6

2

20

Small-scale

0.602

High

132491

HDGR2
Hepatoma-derived growth factor-related protein 2

2

6

High-throughput

0.601

High

132531

ORC6
Origin recognition complex subunit 6

2

0

Small-scale

0.588

High

132458

BI1
Bax inhibitor 1

2

0

High-throughput

0.580

High

132476

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.580

High

132483

TXIP1
Translin-associated factor X-interacting protein 1

2

0

High-throughput

0.580

High

132469

CAF1A
Chromatin assembly factor 1 subunit A

1

7

Small-scale

0.578

High

132460

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.575

High

132421

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.561

High

132451

TOB1
Protein Tob1

1

1

Small-scale

0.561

High

132508

MCMBP
Mini-chromosome maintenance complex-binding protein

2

0

Small-scale

0.559

High

132522

GOG6A
Golgin subfamily A member 6A

2

20

High-throughput

0.553

High

132523

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

8

High-throughput

0.541

High

132520

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.537

High

132415

ORC5
Origin recognition complex subunit 5

1

7

High-throughput

0.536

High

132444

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

8

High-throughput

0.536

High

132490

MCM10
Protein MCM10 homolog

1

2

High-throughput

0.536

High

132429

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.536

High

132430

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

10

High-throughput

0.536

High

132436

ERCC5
DNA excision repair protein ERCC-5

1

4

High-throughput

0.536

High

132456

HMGA2
High mobility group protein HMGI-C

1

1

High-throughput

0.536

High

132459

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.536

High

132461

RACK1
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.536

High

132467

TWF1
Twinfilin-1

1

5

High-throughput

0.536

High

132478

I13R2
Interleukin-13 receptor subunit alpha-2

1

3

High-throughput

0.536

High

132485

RM02
Large ribosomal subunit protein uL2m

1

2

High-throughput

0.536

High

132503

TF2H4
General transcription factor IIH subunit 4

1

1

High-throughput

0.536

High

132515

IF122
Intraflagellar transport protein 122 homolog

1

10

High-throughput

0.536

High

132518

SEC12
Guanine nucleotide-exchange factor SEC12

1

15

High-throughput

0.536

High

132410

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.515

High

132494

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.515

High

132425

TSPYA
Testis-specific Y-encoded protein 10

1

10

High-throughput

0.515

High

132445

HD
Huntingtin

1

5

High-throughput

0.515

High

132486

Q6FHY5
MEOX2 protein

1

5

High-throughput

0.515

High

132424

ERCC1
DNA excision repair protein ERCC-1

1

0

High-throughput

0.513

High

132432

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.513

High

132437

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.513

High

132464

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

132475

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.513

High

132489

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

132504

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

132423

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

132433

ALAT1
Alanine aminotransferase 1

1

3

High-throughput

0.494

High

132530

ICE1
Little elongation complex subunit 1

1

0

High-throughput

0.493

High

132447

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.489

High

132465

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

1

High-throughput

0.489

High

132481

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.489

High

132498

GT251
Procollagen galactosyltransferase 1

1

1

High-throughput

0.489

High

132506

HIPL1
HHIP-like protein 1

1

2

High-throughput

0.489

High

132439

MCM5
DNA replication licensing factor MCM5

1

20

Small-scale

0.481

High

132449

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.481

High

132463

TSPY1
Testis-specific Y-encoded protein 1

1

10

High-throughput

0.481

High

132471

ORC1
Origin recognition complex subunit 1

1

7

Small-scale

0.481

High

132493

HOMEZ
Homeobox and leucine zipper protein Homez

1

1

High-throughput

0.481

High

132501

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

Small-scale

0.480

High

132411

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

132412

XPO1
Exportin-1

1

17

High-throughput

0.479

High

132414

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

132416

PSIP1
PC4 and SFRS1-interacting protein

1

4

High-throughput

0.479

High

132417

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

132422

P53
Cellular tumor antigen p53

1

11

High-throughput

0.479

High

132468

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

132473

CUL3
Cullin-3

1

13

High-throughput

0.479

High

132474

TF2H2
General transcription factor IIH subunit 2

1

1

High-throughput

0.479

High

132479

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

132492

SHLD2
Shieldin complex subunit 2

1

1

High-throughput

0.479

High

132495

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

9

Small-scale

0.479

High

132507

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

132513

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

132516

CPAP
Centrosomal P4.1-associated protein

1

20

High-throughput

0.479

High

132533

Q9Y6T4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

1

High-throughput

0.470

High

132446

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

132420

NDUB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

1

High-throughput

0.439

High

132482

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

132519

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

132462

BAT1
b(0,+)-type amino acid transporter 1

1

7

High-throughput

0.407

High

132488

T2H2L
General transcription factor IIH subunit 2-like protein

1

1

High-throughput

0.407

High

132499

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

132509

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

2

High-throughput

0.407

High

132527

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.407

High

132502

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

132426

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025