HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: AINX (Q16352)
Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)
Gene: INA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 499
+	Hs
		437191 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		AINX_HUMAN (1-499): 5.55e-174: 500: 100.00
+	Hs
		437239 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C28_HUMAN (19-465): 6.11e-135: 399: 26.96
+	Hs
		437057 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		NFM_HUMAN (9-480): 1.72e-96: 313: 47.43
+	Hs
		437056 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		NFL_HUMAN (70-408): 3.36e-97: 305: 58.11
+	Hs
		437061 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		VIME_HUMAN (73-418): 2.3e-96: 301: 54.91
+	Hs
		437114 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		PERI_HUMAN (11-430): 6.26e-88: 279: 50.12
+	Hs
		437084 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		DESM_HUMAN (57-418): 4.73e-85: 271: 51.38
+	Hs
		437078 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		GFAP_HUMAN (62-417): 1.16e-82: 264: 49.44
+	Hs
		227198 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KRT86_HUMAN (6-407): 7.56e-82: 263: 30.60
+	Hs
		341724 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C75_HUMAN (2-410): 1.43e-74: 247: 30.92
+	Hs
		437215 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C79_HUMAN (7-410): 3.56e-71: 237: 28.88
+	Hs
		437198 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C71_HUMAN (6-410): 1.4e-70: 235: 30.27
+	Hs
		437176 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C72_HUMAN (10-410): 1.19e-68: 230: 29.53
+	Hs
		437077 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C5_HUMAN (59-410): 3.26e-62: 215: 31.07
+	Hs
		437236 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C74_HUMAN (30-410): 4.48e-63: 215: 31.59
+	Hs
		407237 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6B_HUMAN (59-410): 3.02e-62: 214: 30.23
+	Hs
		437121 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6C_HUMAN (59-410): 3.91e-62: 214: 30.51
+	Hs
		385216 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6A_HUMAN (59-410): 1.32e-60: 210: 30.51
+	Hs
		437172 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1H2_HUMAN (41-407): 6.36e-62: 210: 27.99
+	Hs
		300545 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KRT36_HUMAN (2-407): 4.29e-60: 206: 29.66