HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RFWD3 (Q6PCD5)
E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)
Gene: RFWD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	38803224
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 774
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (283-645): 1.97e-56: 202: 13.90
+	Hs
		475608 UBC_HUMAN (1-685): 0: 846: 100.00		RNF4_HUMAN (160-344): 2.15e-37: 140: 20.00
+	Hs
		476254 UBC_HUMAN (1-685): 0: 846: 100.00		RING2_HUMAN (234-441): 1.9e-31: 127: 15.39
+	Hs
		476301 UBC_HUMAN (1-685): 0: 846: 100.00		RN126_HUMAN (127-338): 1.78e-29: 121: 16.06
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (283-513): 9.24e-27: 116: 13.07
+	Hs
		475658 UBC_HUMAN (1-685): 0: 846: 100.00		RING1_HUMAN (238-402): 5.7e-25: 110: 17.58
+	Hs
		476188 UBC_HUMAN (1-685): 0: 846: 100.00		RN125_HUMAN (254-405): 1.16e-23: 102: 24.05
+	At
		1210477 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		Q9FM98_ARATH (208-393): 2.48e-26: 113: 15.42
+	At
		1092053 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9FM98_ARATH (208-393): 2.48e-26: 113: 15.42
+	At
		1091813 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RNG1L_ARATH (172-364): 6.54e-26: 111: 12.18
+	At
		477669 UBQ11_ARATH (533-685): 2.54e-59: 201: 95.43		Q9FM98_ARATH (208-393): 2.48e-26: 113: 15.42
+	Hs
		475177 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TRIM5_HUMAN (283-645): 1.97e-56: 202: 13.90
+	Mm
		476947 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN126_MOUSE (127-338): 1.44e-28: 118: 16.36
+	Mm
		476987 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN181_MOUSE (215-377): 1.04e-27: 111: 17.06
+	Hs
		475173 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN126_HUMAN (127-338): 1.78e-29: 121: 16.06