HitPredict

Interactor 1: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Interactor 2: GBG3 (P63215)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene: GNG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 75
+	Hs
		989826 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG3_HUMAN (1-75): 2.05e-30: 103: 100.00
+	Hs
		893553 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG4_HUMAN (1-75): 4.63e-29: 100: 69.33
+	Hs
		948054 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG2_HUMAN (5-75): 2.65e-28: 98.2: 76.06
+	Hs
		475926 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG4_HUMAN (1-75): 4.63e-29: 100: 69.33
+	Hs
		418646 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GBG3_HUMAN (1-75): 2.05e-30: 103: 100.00
+	Hs
		243468 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG7_HUMAN (7-75): 5.92e-25: 89.3: 60.87
+	Hs
		989890 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG8_HUMAN (7-75): 6.38e-25: 89.3: 56.52
+	Hs
		418625 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GBG4_HUMAN (1-75): 4.63e-29: 100: 69.33
+	Hs
		989887 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG12_HUMAN (8-75): 1.13e-23: 86.3: 60.29
+	Hs
		418632 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GBG2_HUMAN (5-75): 2.65e-28: 98.2: 76.06
+	Hs
		893567 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG10_HUMAN (7-75): 2.49e-22: 82.8: 50.73
+	Hs
		243463 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG7_HUMAN (7-75): 5.92e-25: 89.3: 60.87
+	Hs
		476058 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG8_HUMAN (7-75): 6.38e-25: 89.3: 56.52
+	Hs
		989827 GNAI1_HUMAN (1-354): 4.67e-179: 502: 93.79		GBG5_HUMAN (7-75): 1.43e-21: 80.9: 46.38
+	Hs
		476053 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG12_HUMAN (8-75): 1.13e-23: 86.3: 60.29
+	Hs
		243462 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GBG7_HUMAN (7-75): 5.92e-25: 89.3: 60.87
+	Hs
		475927 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG10_HUMAN (7-75): 2.49e-22: 82.8: 50.73
+	Hs
		475944 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG5_HUMAN (7-75): 1.43e-21: 80.9: 46.38
+	Hs
		418626 GNAI2_HUMAN (1-354): 2.83e-174: 489: 85.92		GBG10_HUMAN (7-75): 2.49e-22: 82.8: 50.73
+	Hs
		475935 GNAI3_HUMAN (1-354): 1.48e-176: 495: 100.00		GBG11_HUMAN (5-74): 9.47e-16: 66.2: 31.51