HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 372
+	Hs
		260735 TOP1_HUMAN (1-765): 0: 932: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		508606 TOP1_HUMAN (1-765): 0: 932: 100.00		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		508682 TOP1_HUMAN (1-765): 0: 932: 100.00		H2A1J_HUMAN (1-125): 2.23e-64: 202: 60.94
+	Hs
		470243 TOP1_HUMAN (1-765): 0: 932: 100.00		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		555561 DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		555503 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Sc
		388068 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		H2A1_YEAST (14-125): 3.15e-41: 143: 65.79
+	Sc
		388069 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		H2A2_YEAST (14-124): 2.55e-41: 143: 65.77